In 1961 Roberts submitted a comprehensive review in which he described the 16 naturally
occurring xanthones identified to that date, of which 5 were of fungal or lichenoid origin. 2 …

Experimenta naturae, like the glucose-6-phosphate dehydrogenase deficiency, indicate that
malaria parasites are highly susceptible to alterations in the redox equilibrium. This offers a …

Xanthones or 9H-xanthen-9-ones (dibenzo-γ-pirone) comprise an important class of
oxygenated heterocycles whose role is well-known in Medicinal Chemistry. The biological …

Xanthones are a class of oxygen containing heterocyclic compounds with a broad range of
biological activities, and they have prominent significance in the field of medicinal chemistry …

Digestion of hemoglobin in the food vacuole of the malaria parasite produces very high
quantities of redox active toxic free heme. Hemozoin (β-hematin) formation is a unique …

Xanthones are a class of secondary metabolites produced by plant organisms. They are
characterized by a wide structural variety and numerous biological activities that make them …

Interactions between antimicrobial agents provide clues as to their mechanisms of action
and influence the combinations chosen for therapy of infectious diseases. In the treatment of …

Malaria, resulting from the parasites of the genus Plasmodium, places an untold burden on
the global population. As recently as 40 years ago, only 1 0 percent of the worlds population …

Oxidative damage is one of the most important pathological consequences of malarial
infections. It affects vital organs of the body manifesting in changes such as splenomegaly …

The erythrocytic development of Plasmodium falciparum is divided into the ring, trophozoite,
and schizont stages based on morphologic assessment. Using highly synchronous ring and …