Until fairly recently, proteases were considered primarily to be protein-degrading enzymes.
However, this view has dramatically changed and proteases are now seen as extremely …

The renin-angiotensin system (RAS) constitutes a key hormonal system in the physiological
regulation of blood pressure through peripheral and central mechanisms. Indeed …

Hypertension is a major risk factor for cardiovascular diseases such as stroke, myocardial
infarction, and heart failure, the leading causes of death in the Western world. Inhibitors of …

Interruption of the renin–angiotensin–aldosterone system has become a leading therapeutic
strategy in the treatment of chronic heart and kidney disease. Angiotensin-converting …

OBJECTIVE—Many of the effects of angiotensin (Ang) II are mediated through specific
plasma membrane receptors. However, Ang II also elicits biological effects from the interior …

Current-generation angiotensin-converting enzyme (ACE) inhibitors are widely used for
cardiovascular diseases, including high blood pressure, heart failure, heart attack and …

Background—Stopping the detrimental effects of the renin-angiotensin system at the most
upstream point of the cascade offers theoretical advantages for cardiovascular protection …

Background The aim of this study was to assess dual renin system intervention with the
maximum recommended doses of aliskiren and valsartan, compared with each drug alone …

Background—Loss of negative feedback inhibition of renin release during chronic treatment
with an angiotensin-converting enzyme (ACE) inhibitor leads to a compensatory rise in renin …

Background—Left ventricular (LV) hypertrophy, a marker of cardiac end-organ damage, is
associated with an increased risk of cardiovascular morbidity and mortality. Inhibitors of the …