Intracellular delivery is a key step in biological research and has enabled decades of
biomedical discoveries. It is also becoming increasingly important in industrial and medical …

Biointerfaces mediate safe and efficient cell manipulation, which is essential for biomedical
innovations in advanced therapies and diagnostics. The biointerface established by vertical …

Materials patterned with high‐aspect‐ratio nanostructures have features on similar length
scales to cellular components. These surfaces are an extreme topography on the cellular …

Intracellular delivery of advanced therapeutics, including biologicals and supramolecular
agents, is complex because of the natural biological barriers that have evolved to protect the …

Conspectus Over the past decade, there has been growing interest in developing
biosensors and devices with nanoscale and vertical topography. Vertical nanostructures …

Mechano-bactericidal surfaces deliver lethal effects to contacting bacteria. Until now, cell
death has been attributed to the mechanical stress imparted to the bacterial cell envelope by …

Establishing techniques to efficiently and nondestructively access the intracellular milieu is
essential for many biomedical and scientific applications, ranging from drug delivery, to …

Engineered cell–nanostructured interfaces generated by vertically aligned silicon nanowire
(SiNW) arrays have become a promising platform for orchestrating cell behavior, function …

One-dimensional nanoneedle-like arrays have emerged as an attractive tool for penetrating
the cell membrane to achieve intracellular applications including drug delivery, electrical …

The dynamic interface between the cellular membrane and 3D nanostructures determines
biological processes and guides the design of novel biomedical devices. Despite the fact …