Anticholinergic, antimicrobial, and anticancer perspectives of atropine: a mini-review

A Mirzaei, MR Mohammadi - Micro Nano Bio Aspects, 2023 - mnba-journal.com
Atropine metabolite as a tropane alkaloid is mainly applied as anticholinergic medication.
Other therapeutic activities such as anticancer and antimicrobial effects have been found for …

Precision cut lung slices: an integrated ex vivo model for studying lung physiology, pharmacology, disease pathogenesis and drug discovery

C Koziol-White, E Gebski, G Cao, RA Panettieri Jr - Respiratory Research, 2024 - Springer
Abstract Precision Cut Lung Slices (PCLS) have emerged as a sophisticated and
physiologically relevant ex vivo model for studying the intricacies of lung diseases, including …

AChE reactivation in precision-cut lung slices following organophosphorus compound poisoning

F Gölitz, J Herbert, F Worek, T Wille - Toxicology Letters, 2024 - Elsevier
Precision-cut lung slices (PCLS) are a suitable model for analyzing the acetylcholinesterase
(AChE) activity and subsequent effects after exposure to organophosphorus (OP) …

[HTML][HTML] No-observed-adverse-effect-level (NOAEL) assessment as an optimized dose of cholinesterase reactivators for the treatment of exposure to warfare nerve …

M Trancart, AS Hanak, C Dambrune, M Madi… - Chemico-Biological …, 2024 - Elsevier
Despite the international convention on the prohibition of chemical weapons ratified in 1997,
the threat of conflicts and terrorist attacks involving such weapons still exists. Among these …

Pharmacological prophylaxis with pyridostigmine bromide against nerve agents adversely impact on airway function in an ex vivo rat precision-cut lung slice model

E Wigenstam, E Artursson, A Bucht… - Toxicology Mechanisms …, 2023 - Taylor & Francis
The carbamate pyridostigmine bromide (PB) is the only fielded pharmacological prophylaxis
for military use against nerve agents. Previous studies have shown differences in the PB …

LC and LC-MS/MS studies for identification and characterization of degradation products of d-tubocurarine chloride

P Grover, S Maheshwari, K Nagarajan, L Mehta… - … of Pharmaceutical and …, 2023 - Elsevier
Forced degradation studies of d-tubocurarine (DTC) was carried out in hydrolytic (acidic,
alkaline and neutral), thermal, photolytic and oxidative degradation conditions as per …

[HTML][HTML] Cellular responses following ex vivo lung exposure to the nerve agent VX–Potential for additional treatment targets?

E Wigenstam, A Bucht, L Thors - Chemico-Biological Interactions, 2024 - Elsevier
Following inhalation exposure to organophosphorus nerve agents, symptoms rapidly
develop and severe respiratory symptoms, such as bronchorrhea and bronchoconstriction …

Green and accurate analytical method for monitoring atropine in foodstuffs as a contaminant and in pharmaceutical samples

Y Hamidian, R Mostafazadeh, N Erk… - Journal of Food …, 2023 - Springer
Nowadays, atropine has been highlighted because of its anticholinergic effect and
contamination in foodstuffs, and therefore, using an accurate and sensitive method for its …

[HTML][HTML] How does organophosphorus chemical warfare agent exposure affect respiratory physiology in mice?

M Trancart, A Botta, C Le Coz, N Guatto, AG Calas… - Toxicology, 2024 - Elsevier
In the absence of appropriate medical care, exposure to organophosphorus nerve agents,
such as VX, can lead to respiratory failure, and potentially death by asphyxiation. Despite …

What Is Nicotine Poisoning

TA Khalek - my.klarity.health
What Is Nicotine Poisoning - Klarity Health Library Browse Conditions Angina Asthma Blood
Pressure Bronchitis Cancer Coronary Heart Disease COVID-19 Crohn's Disease …