Crystal engineering of pharmaceutical cocrystals in the discovery and development of improved drugs
The subject of crystal engineering started in the 1970s with the study of topochemical
reactions in the solid state. A broad chemical definition of crystal engineering was published …
reactions in the solid state. A broad chemical definition of crystal engineering was published …
Cocrystal engineering: a collaborative strategy toward functional materials
Cocrystal engineering with a noncovalent assembly feature by simple constituent units has
inspired great interest and has emerged as an efficient and versatile route to construct …
inspired great interest and has emerged as an efficient and versatile route to construct …
Creating organic functional materials beyond chemical bond synthesis by organic cocrystal engineering
L Sun, W Zhu, X Zhang, L Li, H Dong… - Journal of the American …, 2021 - ACS Publications
Organic cocrystal engineering refers to two or more organic molecules stoichiometrically
combined and held together by noncovalent intermolecular interactions, which differs from …
combined and held together by noncovalent intermolecular interactions, which differs from …
Halogen-bonded shape memory polymers
Halogen bonding (XB), a non-covalent interaction between an electron-deficient halogen
atom and a Lewis base, is widely adopted in organic synthesis and supramolecular crystal …
atom and a Lewis base, is widely adopted in organic synthesis and supramolecular crystal …
Crystal engineering strategies towards halogen-bonded metal–organic multi-component solids: Salts, cocrystals and salt cocrystals
Over the past several decades, halogen bonding has become a standard 'tool'in
supramolecular chemistry and particularly in crystal engineering. Traditionally, the study of …
supramolecular chemistry and particularly in crystal engineering. Traditionally, the study of …
Principles and Applications of CF2X Moieties as Unconventional Halogen Bond Donors in Medicinal Chemistry, Chemical Biology, and Drug Discovery
S Vaas, MO Zimmermann, D Schollmeyer… - Journal of Medicinal …, 2023 - ACS Publications
As an orthogonal principle to the established (hetero) aryl halides, we herein highlight the
usefulness of CF2X (X= Cl, Br, or I) moieties. Using tool compounds bearing CF2X moieties …
usefulness of CF2X (X= Cl, Br, or I) moieties. Using tool compounds bearing CF2X moieties …
Unravelling the potential of sigma hole-assisted co-crystallization: Highlighting recent developments
In the past several decades, the field of cocrystal engineering has developed into a vital
research topic in supramolecular chemistry, holding the foremost scope in crystal …
research topic in supramolecular chemistry, holding the foremost scope in crystal …
Co-crystal synthesis: fact, fancy, and great expectations
CA Gunawardana, CB Aakeröy - Chemical Communications, 2018 - pubs.rsc.org
From discrete and dispersed to condensed and organized, directed assembly provides a
link between molecular structure and macroscopic properties. If we are able to combine …
link between molecular structure and macroscopic properties. If we are able to combine …
Halogen-bonded cocrystallization with phosphorus, arsenic and antimony acceptors
The formation of non-covalent directional interactions, such as hydrogen or halogen bonds,
is a central concept of materials design, which hinges on using small compact atoms of the …
is a central concept of materials design, which hinges on using small compact atoms of the …
Synthesis of ternary cocrystals, salts, and hydrates of acefylline with enhanced dissolution and high permeability
Acefylline (ACF) is a stimulant xanthine derivative drug, which is formulated as a piperazine
salt for the treatment of bronchial asthma. ACF falls under BCS class IV category of low …
salt for the treatment of bronchial asthma. ACF falls under BCS class IV category of low …