The minichromosome maintenance (or MCM) protein family is composed of six related
proteins that are conserved in all eukaryotes. They were first identified by genetic screens in …

Initiation and completion of DNA replication defines the beginning and ending of S phase of
the cell cycle. Successful progression through S phase requires that replication be properly …

Cyclin-dependent kinases (CDKs) drive major cell cycle events including the initiation of
chromosomal DNA replication. We identified two S phase CDK (S-CDK) phosphorylation …

Eukaryotic chromosomal DNA replication requires a two-step assembly of replication
proteins on origins; formation of the prereplicative complex (pre-RC) in late M and G1 …

Cdc45, which binds to the minichromosomal maintenance (Mcm) proteins, has a pivotal role
in the initiation and elongation steps of chromosomal DNA replication in eukaryotes. Here …

The numerous processes that damage DNA are counterbalanced by a complex network of
repair pathways that, collectively, can mend diverse types of damage. Insights into these …

Topoisomerase IIβ-binding protein (TopBP1), a human protein with eight BRCT domains, is
similar toSaccharomyces cerevisiae Dpb11 andSchizosaccharomyces pombe Cut5 …

We have identified Xenopus homologs of the budding yeast Sld5 and its three interacting
proteins. These form a novel complex essential for the initiation of DNA replication in …

Human TopBP1 contains nine BRCT domains and functions in DNA replication initiation,
checkpoint signalling, DNA repair and influences transcriptional control. TopBP1 and its …

Abstract BRCA1 carboxyl-terminal (BRCT) motifs are present in a number of proteins
involved in DNA repair and/or DNA damage-signaling pathways. Human DNA …