During malignant transformation, glycosylation is heavily altered compared with healthy
tissue due to differential expression of glycosyltransferases, glycosidases and …

Post-translational modifications (PTMs) are known to be essential mechanisms used by
eukaryotic cells to diversify their protein functions and dynamically coordinate their signaling …

Human blastocyst-derived, pluripotent cell lines are described that have normal karyotypes,
express high levels of telomerase activity, and express cell surface markers that characterize …

Stem cells capable of differentiating to multiple lineages may be valuable for therapy. We
report the isolation of human and rodent amniotic fluid–derived stem (AFS) cells that express …

Human pluripotent stem cells would be invaluable for in vitro studies of aspects of human
embryogenesis. With the goal of establishing pluripotent stem cell lines, gonadal ridges and …

Gangliosides are sialic acid-containing glycosphingolipids that are most abundant in the
nervous system. Heterogeneity and diversity of the structures in their carbohydrate chains …

Embryonic stem cells have the ability to remain undifferentiated and proliferate indefinitely in
vitro while maintaining the potential to differentiate into derivatives of all three embryonic …

Abstract The International Stem Cell Initiative characterized 59 human embryonic stem cell
lines from 17 laboratories worldwide. Despite diverse genotypes and different techniques …

▪ Abstract Researchers have long predicted that complex carbohydrates on cell surfaces
would play important roles in developmental processes because of the observation that …

We have explored the use of embryonic stem cells as an alternative to oocytes for
reprogramming human somatic nuclei. Human embryonic stem (hES) cells were fused with …