Applications of machine learning in solid oral dosage form development

H Lou, B Lian, MJ Hageman - Journal of Pharmaceutical Sciences, 2021 - Elsevier
This review comprehensively summarizes the application of machine learning in solid oral
dosage form development over the past three decades. In both academia and industry …

Using a material property library to find surrogate materials for pharmaceutical process development

MS Escotet-Espinoza, S Moghtadernejad, J Scicolone… - Powder technology, 2018 - Elsevier
Material properties are known to have a significant impact on pharmaceutical manufacturing
performance, particularly for solid product processes. Evaluating the performance of a …

Menthosomes, novel ultradeformable vesicles for transdermal drug delivery: optimization and characterization

S Duangjit, Y Obata, H Sano, S Kikuchi… - Biological and …, 2012 - jstage.jst.go.jp
Menthosomes, novel deformable carriers for the enhancement of transdermal delivery are
introduced in this study. Meloxicam (MX)-loaded menthosomes were formulated, and their …

Determination of the optimal cell-penetrating peptide sequence for intestinal insulin delivery based on molecular orbital analysis with self-organizing maps

N Kamei, S Kikuchi, M Takeda-Morishita… - Journal of …, 2013 - Elsevier
Our recent work has shown that the intestinal absorption of insulin can be improved
significantly by coadministration of cell-penetrating peptides (CPPs), especially penetratin …

Phenomenological and residence time distribution models for unit operations in a continuous pharmaceutical manufacturing process

M Escotet Espinoza - 2018 - rucore.libraries.rutgers.edu
Parts of Chapters have been published within a book chapter titled: Process simulation and
control for continuous pharmaceutical manufacturing of solid drug products. The chapter …

Characterization of powder-and tablet properties of different direct compaction grades of mannitol using a Kohonen self-organizing map and a lasso regression model

A Kosugi, KH Leong, H Tsuji, Y Hayashi… - Journal of …, 2020 - Elsevier
The purpose of this study was to accumulate enhanced technical knowledge about the
powder properties of direct compaction grades of mannitol that could lead to new tablet …

Neural computing in pharmaceutical products and process development

J Djuris, S Ibric, Z Djuric - Computer-aided applications in pharmaceutical …, 2013 - Elsevier
This chapter presents a review of the possible applications of methods based on neural
computing in pharmaceutical products and process development. Some of the methods …

A Novel Framework to Aid the Development of Design Space across Multi-Unit Operation Pharmaceutical Processes—A Case Study of Panax Notoginseng Saponins …

F Sun, B Xu, S Dai, Y Zhang, Z Lin, Y Qiao - Pharmaceutics, 2019 - mdpi.com
The fundamental principle of Quality by Design (QbD) is that the product quality should be
designed into the process through an upstream approach, rather than be tested in the …

Study of the contribution of the state of water to the gel properties of a photocrosslinked polyacrylic acid hydrogel using magnetic resonance imaging

Y Onuki, N Hasegawa, C Kida, Y Obata… - Journal of …, 2014 - Elsevier
Photocrosslinked polyacrylic acid (PAA–HEMA) hydrogels are a promising candidate for use
in dermatological patch adhesives. To gain further knowledge about the properties of this …

Membrane microdomain structures of liposomes and their contribution to the cellular uptake efficiency into HeLa cells

Y Onuki, Y Obata, K Kawano, H Sano… - Molecular …, 2016 - ACS Publications
The purpose of this study is to obtain a comprehensive relationship between membrane
microdomain structures of liposomes and their cellular uptake efficiency. Model liposomes …