RORγt, the master transcription factor for cytokine interleukin (IL)-17, is expressed explicitly
in Th17 cells, γδT cells, and type 3 innate lymphoid cells in mice and humans. Since …

Ubiquitination plays a pivotal role in several cellular processes and is critical for protein
degradation and signaling. E3 ubiquitin ligases are the matchmakers in the ubiquitination …

Ubiquitin (Ub) chain formation by homologous to E6AP C-terminus (HECT)-family E3 ligases
regulates vast biology, yet the structural mechanisms remain unknown. We used chemistry …

Ubiquitination, the covalent attachment of ubiquitin to proteins, by E3 ligases of the HECT
(homologous to E6AP C terminus) family is critical in controlling diverse physiological …

Lipid homeostasis is essential for normal cellular functions and dysregulation of lipid
metabolism is highly correlated with human diseases including neurodegenerative …

Ubiquitin ligases (E3 enzymes) transfer ubiquitin from ubiquitin-conjugating (E2) enzymes to
target proteins. By determining the selection of target proteins, modification sites on those …

A growing amount of evidence indicates that the neuronally expressed developmentally
downregulated 4 (NEDD4, also known as NEDD4-1) E3 ligase plays a critical role in a …

Tumorigenesis, tumor growth, and prognosis are highly related to gene alterations and post-
translational modifications (PTMs). Ubiquitination is a critical PTM that governs practically all …

Lys ubiquitination is catalysed by E3 ubiquitin ligases and is central to the regulation of
protein stability and cell signalling in normal and disease states. There are gaps in our …

HECT ubiquitin ligases play essential roles in metazoan development and physiology. The
HECT ligase HUWE1 is central to the cellular stress response by mediating degradation of …