Significance: Intrarenal oxidative stress plays a critical role in the initiation and progression
of diabetic kidney disease (DKD). Enhanced oxidative stress results from overproduction of …

Metabolic and haemodynamic perturbations and their interaction drive the development of
diabetic kidney disease (DKD) and its progression towards end stage renal disease (ESRD) …

Transforming growth factor-β (TGF-β) is a central player in fibrotic disease. Clinical trials with
global inhibitors of TGF-β have been disappointing, suggesting that a more targeted …

Bone marrow-derived mesenchymal stem cells (MSCs) have contributed to the improvement
of diabetic nephropathy (DN); however, the actual mediator of this effect and its role has not …

TGF-β has been implicated as a major pathogenic factor in diabetic nephropathy. This
randomized, double-blind, phase 2 study assessed whether modulating TGF-β1 activity with …

Diabetes is one of the leading causes of kidney disease. Diabetic kidney disease (DKD) is a
major cause of end-stage kidney disease (ESKD) worldwide, and it is linked to an increase …

OBJECTIVE To determine whether dietary compounds targeting NFE2-related factor 2 (Nrf2)
activation can be used to attenuate renal damage and preserve renal function during the …

Diabetic nephropathy is the most common cause of end-stage renal disease in the US
Recent studies demonstrate that loss of podocytes is an early feature of diabetic …

Chronic and acute renal diseases, irrespective of the initiating cause, have inflammation and
immune system activation as a common underlying mechanism. The purpose of this review …

The glomerulus is a highly specialized capillary tuft, which under pressure filters large
amounts of water and small solutes into the urinary space, while retaining albumin and large …