Novel antimicrobial agents for combating antibiotic-resistant bacteria

RYK Chang, SC Nang, HK Chan, J Li - Advanced drug delivery reviews, 2022 - Elsevier
Antibiotic therapy has become increasingly ineffective against bacterial infections due to the
rise of resistance. In particular, ESKAPE pathogens (Enterococcus faecium, Staphylococcus …

Translating phage therapy into the clinic: Recent accomplishments but continuing challenges

A Petrovic Fabijan, J Iredell, K Danis-Wlodarczyk… - Plos …, 2023 - journals.plos.org
Phage therapy is a medical form of biological control of bacterial infections, one that uses
naturally occurring viruses, called bacteriophages or phages, as antibacterial agents …

Phage Therapy of Mycobacterium Infections: Compassionate Use of Phages in 20 Patients With Drug-Resistant Mycobacterial Disease

RM Dedrick, BE Smith, M Cristinziano… - Clinical infectious …, 2023 - academic.oup.com
Abstract Background Nontuberculous Mycobacterium infections, particularly Mycobacterium
abscessus, are increasingly common among patients with cystic fibrosis and chronic …

Current clinical landscape and global potential of bacteriophage therapy

NM Hitchcock, D Devequi Gomes Nunes, J Shiach… - Viruses, 2023 - mdpi.com
In response to the global spread of antimicrobial resistance, there is an increased demand
for novel and innovative antimicrobials. Bacteriophages have been known for their potential …

Immunogenicity of bacteriophages

K Champagne-Jorgensen, T Luong, T Darby… - Trends in …, 2023 - cell.com
Hundreds of trillions of diverse bacteriophages (phages) peacefully thrive within and on the
human body. However, whether and how phages influence their mammalian hosts is poorly …

Mycobacteriophages: from petri dish to patient

GF Hatfull - PLoS Pathogens, 2022 - journals.plos.org
Mycobacteriophages—bacteriophages infecting Mycobacterium hosts—contribute
substantially to our understanding of viral diversity and evolution, provide resources for …

Mycobacterium smegmatis: the vanguard of mycobacterial research

IL Sparks, KM Derbyshire, WR Jacobs Jr… - Journal of …, 2023 - Am Soc Microbiol
The genus Mycobacterium contains several slow-growing human pathogens, including
Mycobacterium tuberculosis, Mycobacterium leprae, and Mycobacterium avium …

The mechanism of bacterial resistance and potential bacteriostatic strategies

F Zhang, W Cheng - Antibiotics, 2022 - mdpi.com
Bacterial drug resistance is rapidly developing as one of the greatest threats to human
health. Bacteria will adopt corresponding strategies to crack the inhibitory effect of antibiotics …

Therapeutically useful mycobacteriophages BPs and Muddy require trehalose polyphleates

KS Wetzel, M Illouz, L Abad, HG Aull, DA Russell… - Nature …, 2023 - nature.com
Mycobacteriophages show promise as therapeutic agents for non-tuberculous
mycobacterium infections. However, little is known about phage recognition of …

A century of clinical use of phages: a literature review

K Diallo, A Dublanchet - Antibiotics, 2023 - mdpi.com
Growing antibiotic resistance and the broken antibiotic market have renewed interest in the
use of phages, a century-old therapy that fell into oblivion in the West after two decades of …