Mitochondrial quality control in health and in Parkinson's disease

MA Eldeeb, RA Thomas, MA Ragheb… - Physiological …, 2022 - journals.physiology.org
As a central hub for cellular metabolism and intracellular signaling, the mitochondrion is a
pivotal organelle, dysfunction of which has been linked to several human diseases including …

Mitochondrial oxidative stress—a causative factor and therapeutic target in many diseases

P Kowalczyk, D Sulejczak, P Kleczkowska… - International journal of …, 2021 - mdpi.com
The excessive formation of reactive oxygen species (ROS) and impairment of defensive
antioxidant systems leads to a condition known as oxidative stress. The main source of free …

Programmed cell death detection methods: a systematic review and a categorical comparison

S Kari, K Subramanian, IA Altomonte, A Murugesan… - Apoptosis, 2022 - Springer
Programmed cell death is considered a key player in a variety of cellular processes that
helps to regulate tissue growth, embryogenesis, cell turnover, immune response, and other …

Chronic adipose tissue inflammation linking obesity to insulin resistance and type 2 diabetes

F Zatterale, M Longo, J Naderi, GA Raciti… - Frontiers in …, 2020 - frontiersin.org
Obesity is one of the major health burdens of the 21st century as it contributes to the growing
prevalence of its related comorbidities, including insulin resistance and type 2 diabetes …

Role of cardiolipin in mitochondrial function and dynamics in health and disease: molecular and pharmacological aspects

G Paradies, V Paradies, FM Ruggiero, G Petrosillo - Cells, 2019 - mdpi.com
In eukaryotic cells, mitochondria are involved in a large array of metabolic and bioenergetic
processes that are vital for cell survival. Phospholipids are the main building blocks of …

Defective mitophagy in Alzheimer's disease

JA Pradeepkiran, PH Reddy - Ageing Research Reviews, 2020 - Elsevier
Alzheimer's disease (AD) is a progressive, mental illness without cure. Several years of
intense research on postmortem AD brains, cell and mouse models of AD have revealed …

CO2 in indoor environments: From environmental and health risk to potential renewable carbon source

LR López, P Dessì, A Cabrera-Codony… - Science of the total …, 2023 - Elsevier
In the developed world, individuals spend most of their time indoors. Poor Indoor Air Quality
(IAQ) has a wide range of effects on human health. The burden of disease associated with …

[HTML][HTML] Diabetes mellitus: Classification, mediators, and complications; A gate to identify potential targets for the development of new effective treatments

SA Antar, NA Ashour, M Sharaky, M Khattab… - Biomedicine & …, 2023 - Elsevier
Nowadays, diabetes mellitus has emerged as a significant global public health concern with
a remarkable increase in its prevalence. This review article focuses on the definition of …

Physiological barriers and strategies of lipid‐based nanoparticles for nucleic acid drug delivery

M Hu, X Li, Z You, R Cai, C Chen - Advanced Materials, 2024 - Wiley Online Library
Lipid‐based nanoparticles (LBNPs) are currently the most promising vehicles for nucleic
acid drug (NAD) delivery. Although their clinical applications have achieved success, the …

Regulation of lipid peroxidation and ferroptosis in diverse species

M Conrad, VE Kagan, H Bayir… - Genes & …, 2018 - genesdev.cshlp.org
Lipid peroxidation is the process by which oxygen combines with lipids to generate lipid
hydroperoxides via intermediate formation of peroxyl radicals. Vitamin E and coenzyme Q …