ATP, an attractive target for the treatment of refractory chronic cough

M Zhang, DL Sykes, LR Sadofsky, AH Morice - Purinergic Signalling, 2022 - Springer
Chronic cough is the most common complaint in respiratory clinics. Most of them have
identifiable causes and some may respond to common disease-modifying therapies …

[HTML][HTML] WAO-ARIA consensus on chronic cough–Part III: Management strategies in primary and cough-specialty care. Updates in COVID-19

PW Rouadi, SA Idriss, J Bousquet, TM Laidlaw… - World Allergy …, 2022 - Elsevier
Background Chronic cough management necessitates a clear integrated care pathway
approach. Primary care physicians initially encounter the majority of chronic cough patients …

A novel P2X2‐dependent purinergic mechanism of enteric gliosis in intestinal inflammation

R Schneider, P Leven, T Glowka… - EMBO molecular …, 2021 - embopress.org
Enteric glial cells (EGC) modulate motility, maintain gut homeostasis, and contribute to
neuroinflammation in intestinal diseases and motility disorders. Damage induces a reactive …

Intrapulmonary IFN-γ instillation causes chronic lymphocytic inflammation in the spleen and lung through the CXCR3 pathway

W Ding, D Xu, F Li, C Huang, T Song, N Zhong… - International …, 2023 - Elsevier
Some patients with chronic refractory cough have high levels of pulmonary IFN-γ and IFN-γ-
producing T lymphocytes. Pulmonary IFN-γ administration causes acute airway lymphocytic …

Evaluation methods and influencing factors of cough sensitivity

H Mei, W Gu, L Ran, S Wen, L Yu… - Therapeutic Advances in …, 2022 - journals.sagepub.com
Increased cough sensitivity is an important mechanism of chronic cough, and the evaluation
of cough sensitivity helps understand the mechanism of cough and explore better methods …

Similarities and differences between the cough suppression test and the cough challenge test

K Zhao, X Bai, S Wen, S Wang… - … in Respiratory Disease, 2023 - journals.sagepub.com
In recent years, a new test method namely the cough suppression test has been proposed to
measure cough suppression in patients with chronic cough. The cough suppression test is a …

Decoding the impact of the placebo response in clinical trials for chronic cough

M Zhang, B Zhang, AH Morice - ERJ Open Research, 2024 - publications.ersnet.org
Chronic cough is a prevalent and challenging condition, with limited treatment options
available. The interpretation of clinical trial results for antitussive drugs is complicated by the …

[HTML][HTML] WAO-ARIA consensus on chronic cough–Part 1: Role of TRP channels in neurogenic inflammation of cough neuronal pathways

PW Rouadi, SA Idriss, J Bousquet, TM Laidlaw… - World Allergy …, 2021 - Elsevier
Background Cough features a complex peripheral and central neuronal network. The
function of the chemosensitive and stretch (afferent) cough receptors is well described but …

Cough and Itch: common mechanisms of irritation in the throat and skin

SG Brooks, J King, JA Smith, G Yosipovitch - Journal of Allergy and Clinical …, 2024 - Elsevier
Cough and itch are protective mechanisms in the body. Cough occurs as a reflex motor
response to foreign body inhalation, while itch is a sensation that similarly evokes a scratch …

[PDF][PDF] 中药药性干预TRPV4-ATP-P2X3 信号通路调控咳嗽作用机制进展

廖承谱, 周燕萍, 丁雯, 纪利, 赵小超 - 亚太传统医药, 2024 - aptm.com.cn
中药药性干预TRPV4-ATP-P2X3信号通路调控咳嗽作用机制进展 Page 1 中药药性干预TRPV4-ATP-P2X3信号
通路 调控咳嗽作用机制进展 廖承谱1,周燕萍2,丁雯3,纪利3* ,赵小超3 (1.浙江大学金华研究院,浙江 …