DNA-RNA hybrids play a physiological role in cellular processes, but often, they represent
non-scheduled co-transcriptional structures with a negative impact on transcription …

Genome instability is a hallmark of cancer, and DNA replication is the most vulnerable
cellular process that can lead to it. Any condition leading to high levels of DNA damage will …

The human genome contains thousands of long non-coding RNAs, but specific biological
functions and biochemical mechanisms have been discovered for only about a dozen,,,,–. A …

ATP-dependent chromatin remodelers are commonly mutated in human cancer. Mammalian
SWI/SNF complexes comprise three conserved multisubunit chromatin remodelers (cBAF …

R loops are nucleic acid structures composed of an RNA–DNA hybrid and a displaced
single-stranded DNA. Recently, evidence has emerged that R loops occur more often in the …

R loops are three-stranded nucleic acid structures that comprise nascent RNA hybridized
with the DNA template, leaving the nontemplate DNA single-stranded. R loops form naturally …

Transcription poses a threat to genomic stability through the formation of R-loops that can
obstruct progression of replication forks. R-loops are three-stranded nucleic acid structures …

Genome instability is central to ageing, cancer and other diseases. It is not only proteins
involved in DNA replication or the DNA damage response (DDR) that are important for …

CpG islands (CGIs) function as promoters for approximately 60% of human genes. Most of
these elements remain protected from CpG methylation, a prevalent epigenetic modification …

Throughout their lifetimes, messenger RNAs (mRNAs) associate with proteins to form
ribonucleoproteins (mRNPs). Since the discovery of the first mRNP component more than 40 …