ATM, ATR, and DNA-PK: The Trinity at the Heart of the DNA Damage Response
AN Blackford, SP Jackson - Molecular cell, 2017 - cell.com
In vertebrate cells, the DNA damage response is controlled by three related kinases: ATM,
ATR, and DNA-PK. It has been 20 years since the cloning of ATR, the last of the three to be …
ATR, and DNA-PK. It has been 20 years since the cloning of ATR, the last of the three to be …
The essential kinase ATR: ensuring faithful duplication of a challenging genome
JC Saldivar, D Cortez, KA Cimprich - Nature reviews Molecular cell …, 2017 - nature.com
One way to preserve a rare book is to lock it away from all potential sources of damage. Of
course, an inaccessible book is also of little use, and the paper and ink will continue to …
course, an inaccessible book is also of little use, and the paper and ink will continue to …
The ATM protein kinase: regulating the cellular response to genotoxic stress, and more
Y Shiloh, Y Ziv - Nature reviews Molecular cell biology, 2013 - nature.com
The protein kinase ataxia-telangiectasia mutated (ATM) is best known for its role as an
apical activator of the DNA damage response in the face of DNA double-strand breaks …
apical activator of the DNA damage response in the face of DNA double-strand breaks …
Mechanisms of ATM activation
TT Paull - Annual review of biochemistry, 2015 - annualreviews.org
The ataxia-telangiectasia mutated (ATM) protein kinase is a master regulator of the DNA
damage response, and it coordinates checkpoint activation, DNA repair, and metabolic …
damage response, and it coordinates checkpoint activation, DNA repair, and metabolic …
ATM and ATR signaling at a glance
P Awasthi, M Foiani, A Kumar - Journal of cell science, 2015 - journals.biologists.com
ABSTRACT ATM and ATR signaling pathways are well conserved throughout evolution and
are central to the maintenance of genome integrity. Although the role of both ATM and ATR …
are central to the maintenance of genome integrity. Although the role of both ATM and ATR …
Recognition, signaling, and repair of DNA double-strand breaks produced by ionizing radiation in mammalian cells: the molecular choreography
LH Thompson - Mutation Research/Reviews in Mutation Research, 2012 - Elsevier
The faithful maintenance of chromosome continuity in human cells during DNA replication
and repair is critical for preventing the conversion of normal diploid cells to an oncogenic …
and repair is critical for preventing the conversion of normal diploid cells to an oncogenic …
The ATM protein kinase and cellular redox signaling: beyond the DNA damage response
S Ditch, TT Paull - Trends in biochemical sciences, 2012 - cell.com
The ataxia–telangiectasia mutated (ATM) protein kinase is best known for its role in the DNA
damage response, but recent findings suggest that it also functions as a redox sensor that …
damage response, but recent findings suggest that it also functions as a redox sensor that …
ATR autophosphorylation as a molecular switch for checkpoint activation
The ataxia telangiectasia-mutated and Rad3-related (ATR) kinase is a master checkpoint
regulator safeguarding the genome. Upon DNA damage, the ATR-ATRIP complex is …
regulator safeguarding the genome. Upon DNA damage, the ATR-ATRIP complex is …
ATM-dependent and-independent dynamics of the nuclear phosphoproteome after DNA damage
The double-strand break (DSB) is a cytotoxic DNA lesion caused by oxygen radicals,
ionizing radiation, and radiomimetic chemicals. Cells cope with DNA damage by activating …
ionizing radiation, and radiomimetic chemicals. Cells cope with DNA damage by activating …
ATM, ATR and DNA-PKcs kinases—the lessons from the mouse models: inhibition≠ deletion
DNA damage, especially DNA double strand breaks (DSBs) and replication stress, activates
a complex post-translational network termed DNA damage response (DDR). Our review …
a complex post-translational network termed DNA damage response (DDR). Our review …