The evolving view of thermogenic adipocytes—ontogeny, niche and function
The worldwide incidence of obesity and its sequelae, such as type 2 diabetes mellitus, have
reached pandemic levels. Central to the development of these metabolic disorders is …
reached pandemic levels. Central to the development of these metabolic disorders is …
An update on brown adipose tissue biology: a discussion of recent findings
Brown adipose tissue (BAT) has been encouraged as a potential treatment for obesity and
comorbidities due to its thermogenic activity capacity and contribution to energy expenditure …
comorbidities due to its thermogenic activity capacity and contribution to energy expenditure …
[HTML][HTML] The thermogenic activity of adjacent adipocytes fuels the progression of ccRCC and compromises anti-tumor therapeutic efficacy
G Wei, H Sun, K Dong, L Hu, Q Wang, Q Zhuang, Y Zhu… - Cell metabolism, 2021 - cell.com
Clear cell renal cell carcinoma (ccRCC) preferentially invades into perinephric adipose
tissue (PAT), a process associated with poor prognosis. However, the detailed mechanisms …
tissue (PAT), a process associated with poor prognosis. However, the detailed mechanisms …
The GIP receptor activates futile calcium cycling in white adipose tissue to increase energy expenditure and drive weight loss in mice
Obesity is a chronic disease that contributes to the development of insulin resistance, type 2
diabetes (T2D), and cardiovascular risk. Glucose-dependent insulinotropic polypeptide …
diabetes (T2D), and cardiovascular risk. Glucose-dependent insulinotropic polypeptide …
New developments in the biology of fibroblast growth factors
DM Ornitz, N Itoh - WIREs mechanisms of disease, 2022 - Wiley Online Library
The fibroblast growth factor (FGF) family is composed of 18 secreted signaling proteins
consisting of canonical FGFs and endocrine FGFs that activate four receptor tyrosine …
consisting of canonical FGFs and endocrine FGFs that activate four receptor tyrosine …
SIRT7 suppresses energy expenditure and thermogenesis by regulating brown adipose tissue functions in mice
T Yoshizawa, Y Sato, SU Sobuz, T Mizumoto… - Nature …, 2022 - nature.com
Brown adipose tissue plays a central role in the regulation of the energy balance by
expending energy to produce heat. NAD+-dependent deacylase sirtuins have widely been …
expending energy to produce heat. NAD+-dependent deacylase sirtuins have widely been …
[HTML][HTML] Exercise training remodels inguinal white adipose tissue through adaptations in innervation, vascularization, and the extracellular matrix
Inguinal white adipose tissue (iWAT) is essential for the beneficial effects of exercise training
on metabolic health. The underlying mechanisms for these effects are not fully understood …
on metabolic health. The underlying mechanisms for these effects are not fully understood …
Fgf9 regulates bone marrow mesenchymal stem cell fate and bone-fat balance in osteoporosis by PI3K/AKT/Hippo and MEK/ERK signaling
M Chen, H Liang, M Wu, H Ge, Y Ma… - International …, 2024 - pmc.ncbi.nlm.nih.gov
Bone-fat balance is crucial to maintain bone homeostasis. As common progenitor cells of
osteoblasts and adipocytes, bone marrow mesenchymal stem cells (BMSCs) are delicately …
osteoblasts and adipocytes, bone marrow mesenchymal stem cells (BMSCs) are delicately …
Hydroxy-α-sanshool from the fruits of Zanthoxylum bungeanum Maxim. promotes browning of white fat by activating TRPV1 to induce PPAR-γ deacetylation
Q Zhang, CX He, LY Wang, D Qian, DD Tang, SN Jiang… - Phytomedicine, 2023 - Elsevier
Background Accumulating evidence suggested increasing energy expenditure is a feasible
strategy for combating obesity, and browning of white adipose tissue (WAT) to promote …
strategy for combating obesity, and browning of white adipose tissue (WAT) to promote …
m6A mRNA methylation in brown fat regulates systemic insulin sensitivity via an inter-organ prostaglandin signaling axis independent of UCP1
Brown adipose tissue (BAT) regulates systemic metabolism by releasing signaling lipids. N
6-methyladenosine (m 6 A) is the most prevalent and abundant post-transcriptional mRNA …
6-methyladenosine (m 6 A) is the most prevalent and abundant post-transcriptional mRNA …