Highlights•A diverse spectrum of viruses can enter the CNS, causing acute and chronic
neurological disorders.•Virus-induced CNS diseases are influenced by routes of viral entry …

Rabies is a zoonotic disease that remains an important public health problem worldwide
and causes more than 70,000 human deaths each year. The causative agent of rabies is …

Japanese encephalitis is an acute zoonotic, mosquito-borne disease caused by Japanese
encephalitis virus (JEV). Japanese encephalitis is characterized by extensive inflammation …

Infection with laboratory-attenuated rabies virus (RABV) enhances blood-brain barrier (BBB)
permeability, which has been demonstrated to be an important factor for host survival, since …

ABSTRACT A recombinant rabies virus (RV) carrying two identical glycoprotein (G) genes
(SPBNGA-GA) was constructed and used to determine the effect of RV G overexpression on …

Rabies virus (RV) induces encephalomyelitis in humans and animals. However, the
pathogenic mechanism of rabies is not fully understood. To investigate the host responses to …

Apoptosis is associated with virus-induced human diseases of the central nervous system,
heart and liver, and causes substantial morbidity and mortality. Although virus-induced …

Lyssaviruses cause the disease rabies, which is a fatal encephalitic disease resulting in
approximately 59,000 human deaths annually. The prototype species, rabies lyssavirus, is …

Attenuated tissue culture-adapted and natural street rabies virus (RV) strains differ greatly in
their neuroinvasiveness. To identify the elements responsible for the ability of an RV to enter …

Background. This article describes multiple transmissions of rabies via transplanted solid
organ from a single infected donor. The empirical Milwaukee treatment regimen was used in …