Photoreceptor cell death and rescue in retinal detachment and degenerations

Y Murakami, S Notomi, T Hisatomi, T Nakazawa… - Progress in retinal and …, 2013 - Elsevier
Photoreceptor cell death is the ultimate cause of vision loss in various retinal disorders,
including retinal detachment (RD). Photoreceptor cell death has been thought to occur …

[HTML][HTML] Treatment and prevention of pathological mitochondrial dysfunction in retinal degeneration and in photoreceptor injury

WH Moos, DV Faller, IP Glavas, DN Harpp… - Biochemical …, 2022 - Elsevier
Pathological deterioration of mitochondrial function is increasingly linked with multiple
degenerative illnesses as a mediator of a wide range of neurologic and age-related chronic …

Receptor interacting protein kinases mediate retinal detachment-induced photoreceptor necrosis and compensate for inhibition of apoptosis

G Trichonas, Y Murakami, A Thanos… - Proceedings of the …, 2010 - National Acad Sciences
Apoptosis has been shown to be a significant form of cell loss in many diseases.
Detachment of photoreceptors from the retinal pigment epithelium, as seen in various retinal …

Novel properties of tyrosine-mutant AAV2 vectors in the mouse retina

H Petrs-Silva, A Dinculescu, Q Li, WT Deng, J Pang… - Molecular Therapy, 2011 - cell.com
Vectors based on adeno-associated virus serotype 2 (AAV2) have been used extensively in
many gene-delivery applications, including several successful clinical trials for one type of …

Microglia inhibit photoreceptor cell death and regulate immune cell infiltration in response to retinal detachment

Y Okunuki, R Mukai, EA Pearsall… - Proceedings of the …, 2018 - National Acad Sciences
Retinal detachment (RD) is a sight-threatening complication common in many highly
prevalent retinal disorders. RD rapidly leads to photoreceptor cell death beginning within 12 …

Monocyte chemoattractant protein 1 mediates retinal detachment-induced photoreceptor apoptosis

T Nakazawa, T Hisatomi, C Nakazawa… - Proceedings of the …, 2007 - National Acad Sciences
Photoreceptor apoptosis is a major cause of visual loss in retinal detachment (RD) and
several other visual disorders, but the underlying mechanisms remain elusive. Recently …

Correlation between spectral-domain optical coherence tomography findings and visual outcome after primary rhegmatogenous retinal detachment repair

M Gharbiya, F Grandinetti, V Scavella, M Cecere… - Retina, 2012 - journals.lww.com
Purpose: To correlate the postoperative visual outcome with the spectral-domain optical
coherence tomography (SD-OCT) findings in the fovea after successful rhegmatogenous …

Outer nuclear layer thickness at the fovea determines visual outcomes in resolved central serous chorioretinopathy

H Matsumoto, T Sato, S Kishi - American journal of ophthalmology, 2009 - Elsevier
PURPOSE: To determine a correlation between foveal morphologic changes and visual
outcomes in patients with resolved central serous chorioretinopathy (CSC). DESIGN …

Attenuated glial reactions and photoreceptor degeneration after retinal detachment in mice deficient in glial fibrillary acidic protein and vimentin

T Nakazawa, M Takeda, GP Lewis… - … & visual science, 2007 - iovs.arvojournals.org
purpose. To characterize the reactions of retinal glial cells (astrocytes and Müller cells) to
retinal injury in mice that lack glial fibrillary acidic protein (GFAP) and vimentin (GFAP …

Anatomical and functional macular changes after rhegmatogenous retinal detachment with macula off

MP Delolme, B Dugas, F Nicot, A Muselier… - American journal of …, 2012 - Elsevier
PURPOSE: To evaluate the correlation between morphologic changes in the outer retina
and visual function after successful repair of rhegmatogenous retinal detachment with …