Intestinal biofilms: pathophysiological relevance, host defense, and therapeutic opportunities

B Jandl, S Dighe, C Gasche… - Clinical microbiology …, 2024 - journals.asm.org
The human intestinal tract harbors a profound variety of microorganisms that live in
symbiosis with the host and each other. It is a complex and highly dynamic environment …

Current therapies in treatment and prevention of fracture wound biofilms: why a multifaceted approach is essential for resolving persistent infections

KA Blanchette, JC Wenke - Journal of bone and joint infection, 2018 - jbji.copernicus.org
Traumatic orthopedic injuries, particularly extremity wounds, are a significant cause of
morbidity. Despite prophylactic antibiotic treatment and surgical intervention, persistent …

Virtual Screening and Biomolecular Interactions of CviR-Based Quorum Sensing Inhibitors Against Chromobacterium violaceum

V Ravichandran, L Zhong, H Wang, G Yu… - Frontiers in cellular …, 2018 - frontiersin.org
The rise of bacterial multi drug resistance becomes a global threat to the mankind. Therefore
it is essential to find out alternate strategies to fight against these “super bugs.” Quorum …

Identification of new potential inhibitors of quorum sensing through a specialized multi-level computational approach

FG Martins, A Melo, SF Sousa - Molecules, 2021 - mdpi.com
Biofilms are aggregates of microorganisms anchored to a surface and embedded in a self-
produced matrix of extracellular polymeric substances and have been associated with 80 …

Catabolite repression control protein antagonist, a novel player in Pseudomonas aeruginosa carbon catabolite repression control

E Sonnleitner, F Bassani, A Cianciulli Sesso… - Frontiers in …, 2023 - frontiersin.org
In the opportunistic human pathogen Pseudomonas aeruginosa (Pae), c arbon c atabolite r
epression (CCR) orchestrates the hierarchical utilization of N and C sources, and impacts …

Bacterial virulence regulation through soluble peptidoglycan fragments sensing and response: knowledge gaps and therapeutic potential

M Escobar-Salom, IM Barceló… - FEMS microbiology …, 2023 - academic.oup.com
Given the growing clinical–epidemiological threat posed by the phenomenon of antibiotic
resistance, new therapeutic options are urgently needed, especially against top nosocomial …

In Silico Screening of FDA‐Approved Anthelmintic Drugs Against LuxR Protein as Quorum‐Sensing Inhibitors and Exploration of Their Binding Mechanism and …

U Paswan, HK Basak, S Saha, A Chatterjee - ChemistrySelect, 2024 - Wiley Online Library
Treating bacterial infections triggered by multidrug‐resistant bacteria is a global priority.
Issue of multidrug resistance can be managed by inhibiting bacterial quorum sensing …

Approaches to the structure-based design of antivirulence drugs: therapeutics for the post-antibiotic era

N Neville, Z Jia - Molecules, 2019 - mdpi.com
The alarming rise of multidrug-resistant bacterial strains, coupled with decades of stagnation
in the field of antibiotic development, necessitates exploration of new therapeutic …

Growth-phase specific regulation of cviI/R based quorum sensing associated virulence factors in Chromobacterium violaceum by linalool, a monoterpenoid

S Kanekar, RP Devasya - World Journal of Microbiology and …, 2022 - Springer
Quorum sensing (QS)-dependent gene regulation in bacteria performs a vital role in
synchronization of cell-density-dependent functions. In Chromobacterium violaceum QS …

Synthesis of antimicrobial glucosamides as bacterial quorum sensing mechanism inhibitors

NN Biswas, TT Yu, Ö Kimyon, S Nizalapur… - Bioorganic & medicinal …, 2017 - Elsevier
Bacteria communicate with one another and regulate their pathogenicity through a
phenomenon known as quorum sensing (QS). When the bacterial colony reaches a …