Although oral drug delivery is the preferred administration route and has been used for
centuries, modern drug discovery and development pipelines challenge conventional …

Clinical research is an alternative terminology used to describe medical research. Clinical
research involves people, and it is generally carried out to evaluate the efficacy of a …

Physiologically based pharmacokinetic (PBPK) absorption modeling and simulation is
increasingly used as a tool in drug product development, not only in support of clinical …

Ingestible sensor systems are unique tools for obtaining physiological data from an
undisturbed gastrointestinal tract. Since their dimensions correspond to monolithic oral …

Biorelevant dissolution tests of oral solid dosage forms open the gate to valid in vitro-in vivo
predictions (IVIVP). A recently developed apparatus, PhysioCell, allows mimicking the fluid …

Both machine learning and physiologically-based pharmacokinetic models are becoming
essential components of the drug development process. Integrating the predictive …

Physiologically based pharmacokinetic (PBPK) modeling for biopharmaceutics applications
holds great promise as modelling and simulation tool in the field of modern oral modified …

Sustained-release (SR) formulations may appear advantageous in first-in-human (FIH) study
of innovative medicines. The newly developed SR matrix tablets require prolonged …

This chapter aims to demonstrate the value of dissolution within biopharmaceutics and to
highlight the types of apparatus used to better understand the mechanisms associated with …

Abstract The Open Research Biopharmaceutical Internships Support project (ORBIS) was a
response to the scientific, economic, and social challenge of increasing the effectiveness …