[HTML][HTML] Towards frailty biomarkers: Candidates from genes and pathways regulated in aging and age-related diseases

AL Cardoso, A Fernandes, JA Aguilar-Pimentel… - Ageing research …, 2018 - Elsevier
Objective Use of the frailty index to measure an accumulation of deficits has been proven a
valuable method for identifying elderly people at risk for increased vulnerability, disease …

Autoantibody specificities in myasthenia gravis; implications for improved diagnostics and therapeutics

K Lazaridis, SJ Tzartos - Frontiers in immunology, 2020 - frontiersin.org
Myasthenia gravis (MG) is an autoimmune disease characterized by muscle weakness and
fatiguability of skeletal muscles. It is an antibody-mediated disease, caused by …

Advances in the understanding of disease mechanisms of autoimmune neuromuscular junction disorders

MG Huijbers, A Marx, JJ Plomp, R Le Panse… - The Lancet …, 2022 - thelancet.com
Muscle weakness and fatigue are the hallmarks of autoimmune neuromuscular junction
disorders. Although a plethora of immunosuppressive treatments exist, no cure is available …

Myasthenia gravis: pathogenic effects of autoantibodies on neuromuscular architecture

I Koneczny, R Herbst - Cells, 2019 - mdpi.com
Myasthenia gravis (MG) is an autoimmune disease of the neuromuscular junction (NMJ).
Autoantibodies target key molecules at the NMJ, such as the nicotinic acetylcholine receptor …

Understanding the burden of refractory myasthenia gravis

C Schneider-Gold, T Hagenacker… - Therapeutic …, 2019 - journals.sagepub.com
Myasthenia gravis (MG) is an autoantibody-mediated disease that compromises the
acetylcholine receptors or associated structures of the postsynaptic membrane of the …

Myasthenia gravis: autoantibody specificities and their role in MG management

K Lazaridis, SJ Tzartos - Frontiers in neurology, 2020 - frontiersin.org
Myasthenia gravis (MG) is the most common autoimmune disorder affecting the
neuromuscular junction, characterized by skeletal muscle weakness and fatigability. It is …

Clinical features of LRP4/agrin‐antibody–positive myasthenia gravis: A multicenter study

MH Rivner, BM Quarles, JX Pan, Z Yu… - Muscle & …, 2020 - Wiley Online Library
Introduction Our aim in this study was to identify the prevalence and clinical characteristics of
LRP4/agrin‐antibody–positive double‐seronegative myasthenia gravis (DNMG). Methods …

[HTML][HTML] Antibody therapies in autoimmune neuromuscular junction disorders: approach to myasthenic crisis and chronic management

F Vanoli, R Mantegazza - Neurotherapeutics, 2022 - Elsevier
Myasthenia gravis (MG) is a neurological autoimmune disorder characterized by muscle
weakness and fatigue. It is a B cell–mediated disease caused by pathogenic antibodies …

Novel pathophysiological insights in autoimmune myasthenia gravis

G Masi, KC O'Connor - Current opinion in neurology, 2022 - journals.lww.com
Recent advances in the understanding of autoantibody functionalities are bringing
neuroimmunologists closer to a more detailed appreciation of the mechanisms that govern …

Sarcoglycan alpha mitigates neuromuscular junction decline in aged mice by stabilizing LRP4

K Zhao, C Shen, L Li, H Wu, G Xing… - Journal of …, 2018 - Soc Neuroscience
During aging, acetylcholine receptor (AChR) clusters become fragmented and denervated at
the neuromuscular junction (NMJ). Underpinning molecular mechanisms are not well …