Human reproduction is not considered a highly efficient biological process. Before the end of
the first trimester, 30%–50% of conceptions end in spontaneous abortion. Most losses occur …

The antiphospholipid syndrome (APS), a systemic autoimmune disease characterized by a
hypercoagulability associated to vascular thrombosis and/or obstetric morbidity, is caused …

Context Accelerated atherosclerosis has been described in antiphospholipid syndrome, but
the vascular abnormalities and the underlying mechanisms remain unclear. Objectives To …

Abstract β2-Glycoprotein I (β2GPI) is an evolutionary conserved, abundant circulating
protein. Although its function remains uncertain, accumulated evidence points toward …

The exact mechanisms underlying the role of oxidative stress in the pathogenesis and the
prothrombotic or proinflammatory status of antiphospholipid syndrome (APS) remain …

Antiphospholipid syndrome (APS) is a rare autoimmune disorder with complex
pathogenesis. Studies have shown that oxidative stress may contribute to APS …

Atherothrombosis is a recurrent complication in APS and SLE patients. Oxidative stress has
been suggested as a key player underlying this process. Autoantibodies have been pointed …

Objective. To assess the role of nitrite (NO2−), nitrate (NO3−), and nitrative stress in
thrombotic primary antiphospholipid syndrome (PAPS). Methods. We investigated 46 …

Highlights aPLs are involved in the induction of a pro-oxidative state in APS patients
Oxidative stress is a potential biomarker of thrombosis risk in APS patients Oxidative stress …

Objective To assess the role of Toll‐like receptors (TLRs) in antiphospholipid antibody (aPL)–
mediated vascular abnormalities in patients with primary arterial antiphospholipid syndrome …