Brain cancer, especially the most common type of glioblastoma, is highly invasive and
known as one of the most devastating and deadly neoplasms. Despite surgical and medical …

Gliomas are the most malignant and aggressive form of brain tumors, and account for the
majority of brain cancer related deaths. Malignant gliomas, including glioblastoma are …

Two recurrent mutations, K27M and G34R/V, within histone variant H3. 3 were recently
identified in∼ 50% of pHGGs. Both mutations define clinically and biologically distinct …

Glioblastomas (GBM) are some bad prognosis brain tumors despite a conventional
treatment associating surgical resection and subsequent radio-chemotherapy. Among these …

Background Mounting evidences indicate that circular RNAs (circRNAs) play vital roles in
the development and progression of various cancers. However, the detail functions and …

In vivo studies of human brain cellular function face challenging ethical and practical
difficulties. Animal models are typically used but display distinct cellular differences. One …

Gliomas are amongst the most insidious and destructive types of brain cancer and are
associated with a poor prognosis, frequent recurrences, and extremely high lethality despite …

Novel treatments for glioblastoma (GBM) are urgently needed, particularly those which can
simultaneously target GBM cells' ability to grow and migrate. Herein, we describe a …

NG2 cells represent a fourth major glial cell population in the mammalian central nervous
system (CNS). They arise from discrete germinal zones in mid-gestation embryos and …

Glial pathology is a causal contributor to the striatal neuronal dysfunction of Huntington's
disease (HD). We investigate mutant HTT-associated changes in gene expression by mouse …