More than 150 years after bromide was introduced as the first antiepileptic drug, adverse
effects remain a leading cause of treatment failure and a major determinant of impaired …

Epilepsy is a common neurological disorder that is complicated by psychiatric, cognitive,
and social comorbidities that have become a major target of concern and investigation in …

Treatment decisions in epilepsy need to be individualised on the basis of careful analysis of
the risk-benefit ratio of each available option. Key decision steps include the time at which …

The objective of this study was to characterize the changes in adverse events, seizure
severity, and frequency in response to a pharmaceutical formulation of highly purified …

Drug resistant epilepsy (DRE) is defined as the persistence of seizures despite at least two
syndrome-adapted antiseizure drugs (ASD) used at efficacious daily dose. Despite the …

Purpose: To evaluate the relative contribution of demographic and epilepsy‐related
variables, depressive symptoms, and adverse effects (AEs) of antiepileptic drugs (AEDs) to …

Importance Approximately 8% to 10% of the population will experience a seizure during
their lifetime. Only about 2% to 3% of patients go on to develop epilepsy. Understanding the …

Epilepsy is a heterogeneous clinical condition characterized by recurrent unprovoked
seizures, their causes and complications. The incidence, prevalence and mortality of …

Background: Adverse effects (AEs) of antiepileptic drugs (AEDs) are a major impediment to
optimal dosing for seizure control. Better understanding of clinical properties of AEs is a …

Background Patient‐reported outcomes measures (PROMs) assess a patient's subjective
appraisal of health outcomes from their own perspective. Despite hypothesised benefits that …