Review of the Geant4-DNA simulation toolkit for radiobiological applications at the cellular and DNA level

I Kyriakou, D Sakata, HN Tran, Y Perrot, WG Shin… - Cancers, 2021 - mdpi.com
Simple Summary A brief description of the methodologies to simulate ionizing radiation
transport in biologically relevant matter is presented. Emphasis is given to the physical …

Ionizing radiation and complex DNA damage: quantifying the radiobiological damage using Monte Carlo simulations

KP Chatzipapas, P Papadimitroulas, D Emfietzoglou… - Cancers, 2020 - mdpi.com
Ionizing radiation is a common tool in medical procedures. Monte Carlo (MC) techniques are
widely used when dosimetry is the matter of investigation. The scientific community has …

Report on G4‐Med, a Geant4 benchmarking system for medical physics applications developed by the Geant4 Medical Simulation Benchmarking Group

P Arce, D Bolst, MC Bordage, JMC Brown… - Medical …, 2021 - Wiley Online Library
Background Geant4 is a Monte Carlo code extensively used in medical physics for a wide
range of applications, such as dosimetry, micro‐and nanodosimetry, imaging, radiation …

TOPAS-nBio: an extension to the TOPAS simulation toolkit for cellular and sub-cellular radiobiology

J Schuemann, AL McNamara… - Radiation …, 2019 - meridian.allenpress.com
The TOPAS Monte Carlo (MC) system is used in radiation therapy and medical imaging
research, having played a significant role in making Monte Carlo simulations widely …

Evaluation of early radiation DNA damage in a fractal cell nucleus model using Geant4-DNA

D Sakata, N Lampe, M Karamitros, I Kyriakou, O Belov… - Physica Medica, 2019 - Elsevier
The advancement of multidisciplinary research fields dealing with ionising radiation induced
biological damage–radiobiology, radiation physics, radiation protection and, in particular …

Intercomparison of dose enhancement ratio and secondary electron spectra for gold nanoparticles irradiated by X-rays calculated using multiple Monte Carlo …

WB Li, A Belchior, M Beuve, YZ Chen, S Di Maria… - Physica Medica, 2020 - Elsevier
Purpose Targeted radiation therapy has seen an increased interest in the past decade. In
vitro and in vivo experiments showed enhanced radiation doses due to gold nanoparticles …

Bridging the gap between Monte Carlo simulations and measurements of the LISA Pathfinder test-mass charging for LISA

C Grimani, M Villani, M Fabi, A Cesarini… - Astronomy & …, 2022 - aanda.org
Context. Cubic gold-platinum free-falling test masses (TMs) constitute the mirrors of future
LISA and LISA-like interferometers for low-frequency gravitational wave detection in space …

Dependence of gold nanoparticle radiosensitization on cell geometry

W Sung, SJ Ye, AL McNamara, SJ McMahon… - Nanoscale, 2017 - pubs.rsc.org
The radiosensitization effect of gold nanoparticles (GNPs) has been demonstrated both in
vitro and in vivo in radiation therapy. The purpose of this study was to systematically assess …

Geant4‐DNA track‐structure simulations for gold nanoparticles: the importance of electron discrete models in nanometer volumes

D Sakata, I Kyriakou, S Okada, HN Tran… - Medical …, 2018 - Wiley Online Library
Purpose Gold nanoparticles (GNPs) are known to enhance the absorbed dose in their
vicinity following photon‐based irradiation. To investigate the therapeutic effectiveness of …

Investigation of track structure and condensed history physics models for applications in radiation dosimetry on a micro and nano scale in Geant4

P Lazarakis, S Incerti, V Ivanchenko… - Biomedical Physics …, 2018 - iopscience.iop.org
Monte Carlo methods apply various physical models, either condensed history (CH) or track
structure (TS), to simulate the passage of radiation through matter. Both CH and TS models …