Type 2 diabetes mellitus, a common metabolic and endocrine disorder worldwide, causes
severe health and economic problems. At present, pharmacotherapy involving synthetic …

The insulin gene is expressed almost exclusively in pancreatic β-cells. Metabolic regulation
of insulin gene expression enables the β-cell to maintain adequate stores of intracellular …

Consumption of foods high in saturated fatty acids (FAs) as well as elevated levels of
circulating free FAs are known to be associated with T2D. Though previous studies showed …

Type 1 diabetes is preceded by islet β-cell dysfunction, but the mechanisms leading to β-cell
dysfunction have not been rigorously studied. Because immune cell infiltration occurs prior …

The complexity of tissue-and day time-specific regulation of thousands of clock-controlled
genes (CCGs) suggests that many regulatory mechanisms contribute to the transcriptional …

Cellular identity is established by genetic, epigenetic, and environmental factors that
regulate organogenesis and tissue homeostasis. Although some flexibility in fate potential is …

Production and secretion of insulin from the β-cells of the pancreas is very crucial in
maintaining normoglycaemia. This is achieved by tight regulation of insulin synthesis and …

Aims/hypothesis Effects of the transcription factor v-maf musculoaponeurotic fibrosarcoma
oncogene homologue A (MAFA) on the regulation of beta cell gene expression and function …

Farnesoid X Receptor plays an important role in maintaining bile acid, cholesterol
homeostasis and glucose metabolism. Here we investigated whether FXR is expressed by …

Most people with type 2 diabetes (T2D) have reduced β-cell mass, and apoptosis is a key
factor for this reduction. Previously, we showed that ATF3, an adaptive-response gene, is …