Thyroid hormone receptors/THR genes in human cancer

JM González-Sancho, V Garcı́a, F Bonilla, A Muñoz - Cancer letters, 2003 - Elsevier
Thyroid hormone (triiodothyronine, T3) is a pleiotropic regulator of growth, differentiation and
tissue homeostasis in higher organisms that acts through the control of target gene …

[HTML][HTML] Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance

VR Fantin, J St-Pierre, P Leder - Cancer cell, 2006 - cell.com
Alterations in cellular metabolism are among the most consistent hallmarks of cancer.
Herein we have investigated the relationship between increased aerobic lactate production …

[PDF][PDF] Biological activities of thyroid hormone receptors

A Munoz, J Bernal - European Journal of Endocrinology, 1997 - academia.edu
In recent years a large amount of data has been gathered on the biology of thyroid hormone
receptors. The receptor proteins have been analyzed from the physiological and structural …

Selective increase of the permeability of polarized epithelial cell monolayers by Helicobacter pylori vacuolating toxin.

E Papini, B Satin, N Norais… - The Journal of …, 1998 - Am Soc Clin Investig
The effects of the vacuolating toxin (VacA) released by pathogenic strains of Helicobacter
pylori on several polarized epithelial monolayers were investigated. Trans-epithelial electric …

Nuclear hormone receptor antagonism with AP-1 by inhibition of the JNK pathway

C Caelles, JM González-Sancho… - Genes & …, 1997 - genesdev.cshlp.org
The activity of c-Jun, the major component of the transcription factor AP-1, is potentiated by
amino-terminal phosphorylation on serines 63 and 73 (Ser-63/73). This phosphorylation is …

The estrogen-dependent c-JunER protein causes a reversible loss of mammary epithelial cell polarity involving a destabilization of adherens junctions.

I Fialka, H Schwarz, E Reichmann, M Oft… - The Journal of cell …, 1996 - rupress.org
Members of the epidermal growth factor (EGF) receptor family are known to be specifically
involved in mammary carcinogenesis. As a nuclear target of activated receptors, we …

Expression of thyroid hormone receptor/erbA genes is altered in human breast cancer

JM Silva, G Domínguez, JM González-Sancho… - Oncogene, 2002 - nature.com
The relation between thyroid status and diseases and cancer is unclear. No detailed
analysis of thyroid hormone receptor (TR) expression in human breast cancer has been …

Redifferentiation therapy with retinoids: therapeutic option for advanced follicular and papillary thyroid carcinoma

D Simon, J Koehrle, C Reiners… - World Journal of …, 1998 - Wiley Online Library
During the course of tumor progression the differentiated morphologic and functional
characteristics of differentiated thyroid carcinomas (DTC) disappear. This corresponds to …

Prospectively measured triiodothyronine levels are positively associated with breast cancer risk in postmenopausal women

A Tosovic, AG Bondeson, L Bondeson… - Breast Cancer …, 2010 - Springer
Introduction The potential association between hypo-and hyperthyroid disorders and breast
cancer has been investigated in a large number of studies during the last decades without …

Overexpression of matrix metalloproteinase-10 and matrix metalloproteinase-3 in human diabetic corneas: a possible mechanism of basement membrane and …

M Saghizadeh, DJ Brown, R Castellon, M Chwa… - The American journal of …, 2001 - Elsevier
We have previously described decreased immunostaining of nidogen-1/entactin; laminin
chains α1, α5, β1, γ1; and epithelial integrin α3β1 in human diabetic retinopathy (DR) …