Comparative biology of vertebrate retinal regeneration: restoration of vision through cellular reprogramming

L Todd, TA Reh - Cold Spring Harbor Perspectives in …, 2022 - cshperspectives.cshlp.org
The regenerative capacity of the vertebrate retina varies substantially across species.
Whereas fish and amphibians can regenerate functional retina, mammals do not. In this …

Regulating the formation of Müller glia‐derived progenitor cells in the retina

OB Taylor, HM El‐Hodiri, I Palazzo, L Todd, AJ Fischer - Glia, 2025 - Wiley Online Library
We summarize recent findings in different animal models regarding the different cell‐
signaling pathways and gene networks that influence the reprogramming of Müller glia into …

NF-κB signaling regulates the formation of proliferating Müller glia-derived progenitor cells in the avian retina

I Palazzo, K Deistler, TV Hoang, S Blackshaw… - …, 2020 - journals.biologists.com
Retinal regeneration is robust in some cold-blooded vertebrates, but this process is
ineffective in warm-blooded vertebrates. Understanding the mechanisms that suppress the …

Retinoic acid-signaling regulates the proliferative and neurogenic capacity of Müller glia-derived progenitor cells in the avian retina

L Todd, L Suarez, C Quinn, AJ Fischer - Stem Cells, 2018 - academic.oup.com
In the retina, Müller glia have the potential to become progenitor cells with the ability to
proliferate and regenerate neurons. However, the ability of Müller glia-derived progenitor …

BMP‐and TGFβ‐signaling regulate the formation of Müller glia‐derived progenitor cells in the avian retina

L Todd, I Palazzo, N Squires, N Mendonca, AJ Fischer - Glia, 2017 - Wiley Online Library
Müller glia‐derived progenitor cells (MGPCs) have the capability to regenerate neurons in
the retinas of different vertebrate orders. The formation of MGPCs is regulated by a network …

Nuclear Factor I in neurons, glia and during the formation of Müller glia‐derived progenitor cells in avian, porcine and primate retinas

HM El‐Hodiri, WA Campbell, LE Kelly… - Journal of …, 2022 - Wiley Online Library
The regenerative potential of Müller glia (MG) is extraordinary in fish, poor in chick and
terrible in mammals. In the chick model, MG readily reprogram into proliferating Müller glia …

Chromatin access regulates the formation of Müller glia‐derived progenitor cells in the retina

WA Campbell, HM El‐Hodiri, D Torres, EC Hawthorn… - Glia, 2023 - Wiley Online Library
Chromatin access and epigenetic control over gene expression play important roles in
regulating developmental processes. However, little is known about how chromatin access …

Fatty acid-binding proteins and fatty acid synthase influence glial reactivity and promote the formation of Müller glia-derived progenitor cells in the chick retina

WA Campbell, A Tangeman, HM El-Hodiri… - …, 2022 - journals.biologists.com
ABSTRACT A recent comparative transcriptomic study of Müller glia (MG) in vertebrate
retinas revealed that fatty acid binding proteins (FABPs) are among the most highly …

Heparin-binding EGF-like growth factor (HB-EGF) stimulates the proliferation of Müller glia-derived progenitor cells in avian and murine retinas

L Todd, LI Volkov, C Zelinka, N Squires… - Molecular and Cellular …, 2015 - Elsevier
Müller glia can be stimulated to de-differentiate, proliferate and form Müller glia-derived
progenitor cells (MGPCs) that regenerate retinal neurons. In the zebrafish retina, heparin …

Retinal stem cell 'retirement plans': Growth, regulation and species adaptations in the retinal ciliary marginal zone

A Miles, V Tropepe - International Journal of Molecular Sciences, 2021 - mdpi.com
The vertebrate retina develops from a specified group of precursor cells that adopt distinct
identities and generate lineages of either the neural retina, retinal pigmented epithelium, or …