The 5′ N 7-methylguanosine cap is a critical modification for mRNAs and many other RNAs
in eukaryotic cells. Recent studies have uncovered an RNA 5′ capping quality surveillance …

Conspectus Ribonucleic acid (RNA) is composed primarily of four canonical building blocks.
In addition, more than 170 modifications contribute to its stability and function. Metabolites …

In recent years, several noncanonical RNA caps derived from cofactors and metabolites
have been identified. Purine-containing RNA caps have been extensively studied, with …

While the cellular functions of the coenzyme thiamine (vitamin B1) diphosphate (ThDP) are
well characterized, the triphosphorylated thiamine derivatives, thiamine triphosphate (ThTP) …

The 5′ cap of eukaryotic mRNA is a hallmark for cellular functions from mRNA stability to
translation. However, the discovery of novel 5′‐terminal RNA caps derived from cellular …

All domains of life utilize a diverse set of modified ribonucleotides that can impact the
sequence, structure, function, stability, and the fate of RNAs, as well as their interactions with …

Many eukaryotic and some bacterial RNAs are modified at the 5′ end by the addition of cap
structures. In addition to the classic 7-methylguanosine 5′ cap in eukaryotic mRNA, several …

It was long believed that viral and eukaryotic mRNA molecules are capped at their 5′ end
solely by the N7‐methylguanosine cap, which regulates various aspects of the RNA life …

Abstract Background Adenosine thiamine triphosphate (AThTP) is a nucleotide discovered
in bacteria and some other living organisms more than a decade ago. No biochemical …