BackgroundThe nosology of the psychosis high-risk state is controversial. Traditionally
conceived as an 'at risk'state for the development of psychotic disorders, it is also …

Classical schizophrenia literature reports motor symptoms as characteristic of the disorder.
After the introduction of neuroleptic drugs, the existence of genuine motor disorders was …

Context A substantial proportion of people at clinical high risk of psychosis will develop a
psychotic disorder over time. However, the risk of transition to psychosis varies between …

Background There is considerable interest in a dimensional transdiagnostic approach to
psychiatry. Most transdiagnostic studies have derived factors based only on clinical …

Background The clinical high-risk state for psychosis (HRP) is associated with an enhanced
probability of developing a psychotic episode over a relatively short period of time. However …

Signs of motor dysfunction are evidenced across a range of psychiatric disorders including
schizophrenia. Historically, these features have been neglected but emerging theoretical …

Behavioural abnormalities such as impulse control disorders may develop when patients
with Parkinson's disease receive dopaminergic therapy, although they can be controlled by …

Prospective longitudinal evaluation of adolescents at ultra-high-risk (UHR) for the
development of psychosis enables an enriched neurodevelopmental perspective of disease …

Aims The clinical outcomes of individuals at clinical high risk of psychosis (CHR-P) who do
not transition to psychosis are heterogeneous and inconsistently reported. We aimed to …

The National Institute of Mental Health (NIMH) Research Domain Criteria (RDoC) is
designed to shift research on psychopathology towards a pathophysiology-based framework …