Targeting RNAs with small molecules represents a new frontier in drug discovery and
development. The rich structural diversity of folded RNAs offers a nearly unlimited reservoir …

Fluorescence microscopy of trypanosomes from drug treated mice shows that biologically
active heterocyclic diamidines that target the DNA minor groove bind rapidly and specifically …

Structural studies of the 3′‐end of the oncogenic long non‐coding RNA metastasis‐
associated lung adenocarcinoma transcript 1 (MALAT1) confirmed a unique triple‐helix …

An intermolecular 1, 2-diacylation of alkenes is disclosed via cooperative N-heterocyclic
carbene and photoredox catalysis under the mediation of PPh3 and Cs2CO3. This protocol …

The structural and regulatory elements in therapeutically relevant RNAs offer many
opportunities for targeting by small molecules, yet fundamental understanding of what drives …

Small molecule-based modulation of a triple helix in the long non-coding RNA metastasis-
associated lung adenocarcinoma transcript 1 (MALAT1) has been proposed as an attractive …

Nanoparticle assemblies interconnected with DNA triple helixes can be used to
colorimetrically screen for triplex DNA binding molecules and simultaneously determine …

Herein we report a photocatalytic oxidative radical addition reaction for the synthesis of
unsymmetrical 1, 4-dicarbonyl compounds. This reaction utilizes a desulfurization process to …

Initial successes in developing small molecule ligands for non-coding RNAs have
underscored their potential as therapeutic targets. More recently, these successes have …

RNA structures regulate a wide range of processes in biology and disease, yet small
molecule chemical probes or drugs that can modulate these functions are rare. Machine …