The role of calcium ions (Ca2+) in cell functions is beginning to be unraveled at the
molecular level as a result of recent research on calcium-binding proteins and particularly …

Transient rises in the cytoplasmic concentration of calcium ions serve as second messenger
signals that control many neuronal functions. Selective triggering of these functions is …

Postsynaptic densities (PSDs) have been isolated from cerebral cortex, midbrain,
cerebellum, and brain stem by the Triton X-100 method previously used in the isolation of …

The inhibitory protein that binds calmodulin and thus prevents activation of several Ca2+-
dependent enzymes by calmodulin is shown to also bind four Ca2+ per mol of protein with …

Calmodulin, a protein that binds calcium with high affinity and specificity, is structurally
conserved and functionally preserved throughout the animal and plant kingdoms. It serves …

Specificity of protein kinases and phosphatases may be achieved through
compartmentalization with preferred substrates. In neurons, adenosine 3′, 5 …

Publisher Summary Calmodulin is the major intracellular, and intramembrane, Ca 2+
receptor. Its function is to detect free Ca 2+ and translate changes in Ca 2+ concentrations …

By three criteria, two biochemical and one immunochemical, the major postsynaptic density
protein (mPSDp) is indistinguishable from the 50-kilodalton (kDa) alpha subunit of a brain …

The postsynaptic density (PSD) is a specialization of the (Sanes, 1997). Major
morphological variants of type 1 cytoskeleton at the synaptic junction. It lies adjacent to …

Glutamatergic synapses in the central nervous system are characterized by an electron-
dense web underneath the postsynaptic membrane; this web is called the postsynaptic …