Cells die by a variety of mechanisms. Terminally differentiated cells such as neurones die in
a variety of disorders, in part, via parthanatos, a process dependent on the activity of poly …

Fatty liver disease is one of the most prevalent forms of chronic liver disease that
encompasses both alcoholic liver disease (ALD) and nonalcoholic fatty liver disease …

Apoptosis-inducing factor (AIF) is a flavin adenine dinucleotide-containing, NADH-
dependent oxidoreductase residing in the mitochondrial intermembrane space whose …

Poly (ADP-ribose) polymerase-1 (PARP-1) plays a pivotal role in multiple neurologic
diseases by mediating caspase-independent cell death, which has recently been …

The kidney has long been invoked in the etiology of essential hypertension. This could
involve alterations in expression of specific genes and microRNAs (miRNAs). The aim of the …

Alkylating DNA damage induces a necrotic type of programmed cell death through the poly
(ADP-ribose) polymerases (PARP) and a poptosis-i nducing f actor (AIF). Following PARP …

The heat shock protein (Hsps) superfamily, also known as molecular chaperones, are highly
conserved and present in all living organisms and play vital roles in protein fate. The …

Disruption of cellular functions with aging-induced accumulation of neuronal stressors
causes cell death which is a common feature of neurodegenerative diseases. Studies in a …

Programmed necrosis induced by DNA alkylating agents, such as MNNG, is a caspase‐
independent mode of cell death mediated by apoptosis‐inducing factor (AIF). After poly …

Reactive oxygen species (ROS), a heterogeneous population of biologically active
intermediates, are generated as by-products of the aerobic metabolism and exhibit a dual …