Proliferating cancer cells rely largely on glutamine for survival and proliferation. Glutamine
serves as a carbon source for the synthesis of lipids and metabolites via the TCA cycle, as …

During decades, the research field of cancer metabolism was based on the Warburg effect,
described almost one century ago. Lately, the key role of mitochondria in cancer …

Metabolism rewiring is an important hallmark of cancers. Being one of the most abundant
free amino acids in the human blood, glutamine supports bioenergetics and biosynthesis …

Over the past few years, the field of regulated cell death continues to expand and novel
mechanisms that orchestrate multiple regulated cell death pathways are being unveiled …

Background: Uterine corpus endometrial carcinoma (UCEC) is a common gynecological
malignancy globally with high recurrence and mortality rates. Cuproptosis is a new type of …

Despite an increasing arsenal of anticancer therapies, many patients continue to have poor
outcomes due to the therapeutic failures and tumor relapses. Indeed, the clinical efficacy of …

Glucose, as the main consuming nutrient of the body, faces different destinies in cancer
cells. Glycolysis, oxidative phosphorylation, and pentose phosphate pathways produce …

Targeting glutamine catabolism has been attracting more research attention on the
development of successful cancer therapy. Catalytic enzymes such as glutaminase (GLS) in …

Liver cancer is a generic term referring to several cancer types arising from the liver. Every
year, liver cancer causes lots of deaths and other burdens to the people all over the world …

Targeted therapies against cancer have improved both survival and quality of life of patients.
However, metabolic rewiring evokes cellular mechanisms that reduce therapeutic …