The present review summarizes recent publications devoted to aminoglycosides that study
the main types of resistance to antibiotics of this class and the main directions of chemical …

Complementing our earlier syntheses of the gentamicins B1, C1a, C2b, and X2, we describe
the synthesis of gentamicins C1, C2, and C2a characterized by methyl substitution at the 6 …

Abstract Modification at the 5''‐position of 4, 5‐disubstituted aminoglycoside antibiotics
(AGAs) to circumvent inactivation by aminoglycoside modifying enzymes (AMEs) is well …

We report the synthesis and evaluation of two new apramycin 5‐O‐β‐d‐ribofuranosides, or
apralogs, carrying aminoalkyl branches at the ribofuranose 4‐position. This novel …

The synthesis and antiribosomal and antibacterial activity of both anomers of a novel
apralog, 5-O-(5-amino-3-C-dimethylaminopropyl-D-ribofuranosyl) apramycin, are reported …

We report a concise synthesis of the naturally occurring protein synthesis inhibitor (+)‐
actinobolin (1). The densely functionalized and stereochemically complex molecular …

The site‐selective modification of complex biomolecules by transition metal‐catalysis is
highly warranted, but often thwarted by the presence of Lewis basic functional groups. This …

The design, synthesis and antiribosomal and antibacterial activity of two novel glycosides of
the aminoglycoside antibiotic paromomycin are described. The first carries of 4-amino-4 …

CHAPTER 1: Multidrug-resistant bacteria is a threat to public health and there is a need for
the development of new antibiotics to fight bacterial resistance. Aminoglycoside antibiotics …

Aminoglycosides have been widely recognized as critically important antimicrobials for
treatment of multidrug resistant bacteria. As presented in Chapter 1, though effective against …