Iron overload and its impact on outcome of patients with hematological diseases

GN Franke, AS Kubasch, M Cross, V Vucinic… - Molecular Aspects of …, 2020 - Elsevier
Systemic iron overload (SIO) is a common challenge in patients with hematological diseases
and develops as a result of ineffective erythropoiesis, multiple red blood cell (RBC) …

Role of iron and iron overload in the pathogenesis of invasive fungal infections in patients with hematological malignancies

T Valković, MS Damić - Journal of Clinical Medicine, 2022 - mdpi.com
Iron is an essential trace metal necessary for the reproduction and survival of fungal
pathogens. The latter have developed various mechanisms to acquire iron from their …

Impact of red blood cell transfusion dose density on progression-free survival in patients with lower-risk myelodysplastic syndromes

L de Swart, S Crouch, M Hoeks, A Smith… - …, 2019 - pmc.ncbi.nlm.nih.gov
Progression-free survival (PFS) of patients with lower-risk myelodysplastic syndromes
(MDS) treated with red blood cell transfusions is usually reduced, but it is unclear whether …

Systematic review and meta-analysis of the effect of iron chelation therapy on overall survival and disease progression in patients with lower-risk myelodysplastic …

AM Zeidan, S Giri, M DeVeaux, SK Ballas… - Annals of Hematology, 2019 - Springer
The impact of iron chelation therapy (ICT) on overall survival (OS) and progression to acute
myeloid leukemia (AML) in patients with iron overload and International Prognostic Scoring …

Iron Overload Impairs Bone Marrow Mesenchymal Stromal Cells from Higher‐Risk MDS Patients by Regulating the ROS‐Related Wnt/β‐Catenin Pathway

L Huang, Z Liu, H Liu, K Ding, F Mi… - Stem cells …, 2020 - Wiley Online Library
The bone marrow microenvironment plays important roles in the progression of the
myelodysplastic syndrome (MDS). The higher incidence of ASXL1 and TET2 gene mutations …

Current status and achievements of Polish haemato-oncology

S Giebel, G Basak, M Bieniaszewska… - Acta Haematologica …, 2021 - journals.viamedica.pl
The number of newly diagnosed haematological malignancies in Polish adults and children
is about 9,000 a year, which constitutes about 5.5% of all malignancies in the country. Adult …

Longitudinal proteomics study of serum changes after allogeneic HSCT reveals potential markers of metabolic complications related to aGvHD

SY Wong, S Kato, F Rodenburg, A Tojo, N Hayashi - Scientific Reports, 2022 - nature.com
Even though hematopoietic stem cell transplantation (HSCT) allows successful treatment for
many malignant and non-malignant disorders, its curative potential remains limited by …

[HTML][HTML] A prospective non-interventional study on the impact of transfusion burden and related iron toxicity on outcome in myelodysplastic syndromes undergoing …

EMP Cremers, T de Witte, L de Wreede… - Leukemia & …, 2019 - Taylor & Francis
Most myelodysplastic syndromes (MDS)-patients receive multiple red blood cell transfusions
(RBCT). Transfusions may cause iron-related toxicity and mortality, influencing outcome …

A systematic literature review of the relationship between serum ferritin and outcomes in myelodysplastic syndromes

EN Oliva, K Huey, S Deshpande, M Turner… - Journal of Clinical …, 2022 - mdpi.com
Anemia is the most common form of cytopenia in patients with myelodysplastic syndromes
(MDS), who require chronic red blood cell transfusions and may present high serum ferritin …

Impact of iron overload by transfusion on survival and leukemia transformation of myelodysplastic syndromes in a single center of China

Y Wang, L Huang, Y Hua, H Liu, H Jiang, H Wang… - …, 2021 - Taylor & Francis
Introduction Myelodysplastic syndromes (MDS) are a heterogeneous group of diseases
which are prone to progress into acute myeloid leukemia (AML). Iron overload (IOL) caused …