Nonalcoholic fatty liver disease (NAFLD) has emerged as the most common chronic liver
disease worldwide and is strongly associated with the presence of oxidative stress …

Reactive oxygen species (ROS) are critical for the progression of cardiovascular diseases,
inflammations and tumors. However, the mechanisms of how ROS sense metabolic stress …

Significance: Inflammasomes are multiprotein complexes localized within the cytoplasm of
the cell that are responsible for the maturation of proinflammatory cytokines such as …

The high energy demand of the brain renders it sensitive to changes in energy fuel supply
and mitochondrial function. Deficits in glucose availability and mitochondrial function are …

Significance: Inflammasomes are cytosolic multiprotein complexes that mediate innate
immune pathways. Inflammasomes activate inflammatory caspases and regulate …

Diabetic nephropathy is a growing health concern with characteristic sterile inflammation. As
the underlying mechanisms of this inflammation remain poorly defined, specific therapies …

Kidney injury implies danger signaling and a response by the immune system. The
inflammasome is a central danger recognition platform that triggers local and systemic …

Inflammasomes are components of the innate immune response that have recently emerged
as crucial controllers of tissue homeostasis. In particular, the nucleotide-binding domain …

Salt-sensitivity of blood pressure is an independent risk factor for cardiovascular disease
and affects approximately half of the hypertensive population. While the precise …

Systemic sclerosis is an autoimmune disorder characterized by inflammation and a
progressive fibrosis affecting the skin and visceral organs. Over the last two decades, it …