In spite of the long‐term interest in the process of balancing selection, its frequency in
genomes and evolutionary significance remain unclear due to challenges related to its …

Malaria is the most deadly parasitic disease, affecting hundreds of millions of people
worldwide. Malaria parasites have been associated with their hosts for millions of years …

Acquired immunity in vertebrates maintains polymorphisms in endemic pathogens, leading
to identifiable signatures of balancing selection. To comprehensively survey for genes under …

After more than 50 years of intensive research and development, only one malaria vaccine
candidate,“RTS, S,” has progressed to Phase 3 clinical trials. Despite only partial efficacy …

Successful invasion of human erythrocytes by Plasmodium falciparum merozoites is
required for infection of the host and parasite survival. The early stages of invasion are …

Parasite antigen genes might evolve under frequency-dependent immune selection. The
distinctive patterns of polymorphism that result can be detected using population genetic …

Plasmodium falciparum is the causative agent of the most severe form of malaria in humans.
The merozoite, an extracellular stage of the parasite lifecycle, invades erythrocytes in which …

Background Malaria is a major public health problem in Cameroon. The study of the genetic
diversity within parasite population is essential for understanding the mechanism underlying …

Malaria is considered one of the most important scourges that humanity has faced during its
history, being responsible every year for numerous deaths worldwide. The disease is …

The s48/45 domain was first noted in Plasmodium proteins more than 15 y ago. Previously
believed to be unique to Plasmodium, the s48/45 domain is present in other …