Innate immune memory and the host response to infection

ER Sherwood, KR Burelbach, MA McBride… - The Journal of …, 2022 - journals.aai.org
Unlike the adaptive immune system, the innate immune system has classically been
characterized as being devoid of memory functions. However, recent research shows that …

Inducing trained immunity in pro-metastatic macrophages to control tumor metastasis

C Ding, R Shrestha, X Zhu, AE Geller, S Wu… - Nature …, 2023 - nature.com
Metastasis is the leading cause of cancer-related deaths and myeloid cells are critical in the
metastatic microenvironment. Here, we explore the implications of reprogramming pre …

[HTML][HTML] Polysaccharides—Naturally occurring immune modulators

EJ Murphy, GW Fehrenbach, IZ Abidin, C Buckley… - Polymers, 2023 - mdpi.com
The prevention of disease and infection requires immune systems that operate effectively.
This is accomplished by the elimination of infections and abnormal cells. Immune or …

[HTML][HTML] MyD88-dependent signaling drives toll-like receptor-induced trained immunity in macrophages

AM Owen, L Luan, KR Burelbach, MA McBride… - Frontiers in …, 2022 - frontiersin.org
Immunocompromised populations are highly vulnerable to developing life-threatening
infections. Strategies to protect patients with weak immune responses are urgently needed …

[HTML][HTML] Trained immunity contribution to autoimmune and inflammatory disorders

SC Funes, M Rios, A Fernández-Fierro… - Frontiers in …, 2022 - frontiersin.org
A dysregulated immune response toward self-antigens characterizes autoimmune and
autoinflammatory (AIF) disorders. Autoantibodies or autoreactive T cells contribute to …

[HTML][HTML] Next generation mucosal vaccine strategy for respiratory pathogens

F Dotiwala, AK Upadhyay - Vaccines, 2023 - mdpi.com
Inducing humoral and cytotoxic mucosal immunity at the sites of pathogen entry has the
potential to prevent the infection from getting established. This is different from systemic …

Trained immunity: A Yin‐Yang balance

Z Hu, SH Lu, DB Lowrie, XY Fan - MedComm, 2022 - Wiley Online Library
Traditionally, immune memory is regarded as an exclusive hallmark of adaptive immunity.
However, a growing body of evidence suggesting that innate immune cells show adaptive …

[HTML][HTML] Novel nutraceutical supplements with yeast β-glucan, prebiotics, minerals, and Silybum marianum (silymarin) ameliorate obesity-related metabolic and …

V Nehmi-Filho, AB Santamarina… - Frontiers in …, 2023 - frontiersin.org
Purpose It is known that obesity has a multifactorial etiology that involves genetic and
environmental factors. The WHO estimates the worldwide prevalence of 1.9 billion …

[HTML][HTML] CD115+ monocytes protect microbially experienced mice against E. coli-induced sepsis

MD Martin, C Skon-Hegg, CY Kim, J Xu, TA Kucaba… - Cell reports, 2023 - cell.com
Uropathogenic E. coli (UPEC) is a primary organism responsible for urinary tract infections
and a common cause of sepsis. Microbially experienced laboratory mice, generated by …

[HTML][HTML] Yeast cell wall extracts from Saccharomyces cerevisiae varying in structure and composition differentially shape the innate immunity and mucosal tissue responses of …

M Rawling, M Schiavone, E Apper… - Frontiers in …, 2023 - frontiersin.org
With the rising awareness of antimicrobial resistance, the development and use of functional
feed additives (FFAs) as an alternative prophylactic approach to improve animal health and …