Pathobiology of Japanese encephalitis virus infection

KB Sharma, S Vrati, M Kalia - Molecular Aspects of Medicine, 2021 - Elsevier
Japanese encephalitis virus (JEV) is a flavivirus, spread by the bite of carrier Culex
mosquitoes. The subsequent disease caused is Japanese encephalitis (JE), which is the …

The functional importance of VCP to maintaining cellular protein homeostasis

BA Ahlstedt, R Ganji, M Raman - Biochemical Society …, 2022 - portlandpress.com
The AAA-ATPase (ATPases associated with diverse cellular activities) valosin-containing
protein (VCP), is essential for many cellular pathways including but not limited to …

Methotrimeprazine is a neuroprotective antiviral in JEV infection via adaptive ER stress and autophagy

SK Prajapat, L Mishra, S Khera, SD Owusu… - EMBO Molecular …, 2024 - embopress.org
Japanese encephalitis virus (JEV) pathogenesis is driven by a combination of neuronal
death and neuroinflammation. We tested 42 FDA-approved drugs that were shown to induce …

Recent advances in antivirals for Japanese encephalitis virus

Y Zhu, S Chen, Q Lurong, Z Qi - Viruses, 2023 - mdpi.com
Culex mosquitoes are the primary vectors of the Japanese encephalitis virus (JEV). Since its
discovery in 1935, Japanese encephalitis (JE), caused by JEV, has posed a significant …

[HTML][HTML] Virus-host Interactions in Early Japanese Encephalitis Virus Infection

Y Zhu, Z He, Z Qi - Virus Research, 2023 - Elsevier
Japanese encephalitis virus (JEV) is a mosquito-borne zoonotic virus that can cause severe
viral encephalitis. Initial interactions between JEV and host cells are required for productive …

The biogenesis of dengue virus replication organelles requires the ATPase activity of valosin-containing protein

C Mazeaud, A Anton, F Pahmeier, AA Sow, B Cerikan… - Viruses, 2021 - mdpi.com
The dengue virus (DENV) causes the most prevalent arthropod-borne viral disease
worldwide. While its incidence is increasing in many countries, there is no approved antiviral …

Flavivirus recruits the valosin-containing protein–NPL4 complex to induce stress granule disassembly for efficient viral genome replication

M Arakawa, K Tabata, K Ishida, M Kobayashi… - Journal of Biological …, 2022 - ASBMB
Flaviviruses are human pathogens that can cause severe diseases, such as dengue fever
and Japanese encephalitis, which can lead to death. Valosin-containing protein (VCP)/p97 …

[HTML][HTML] DnaJA2 interacts with Japanese encephalitis virus NS3 via its C-terminal to promote viral infection

L Qin, T Rao, X Li, H Chen, P Qian - Virus Research, 2023 - Elsevier
Numerous studies have documented that the interaction of viral and cellular proteins is
essential in the viral life cycle. In our previous study, to screen cellular proteins that take part …

Japanese encephalitis in Bali, Indonesia: ecological and socio-cultural perspectives

IM Kardena, AAAM Adi, NM Astawa… - … journal of veterinary …, 2021 - Taylor & Francis
The increasing number of cases of acute encephalitis syndrome, a key presenting clinical
sign of Japanese encephalitis infection in humans, along with increasing laboratory …

Japanese encephalitis virus NS5 protein interacts with nucleolin to enhance the virus replication

A Deb, S Nagpal, RK Yadav, H Thakur, D Nair… - Journal of …, 2024 - journals.asm.org
Japanese encephalitis virus (JEV) is an arthropod-borne, plus-strand flavivirus causing viral
encephalitis in humans with a high case fatality rate. The JEV non-structural protein 5 (NS5) …