Artemisinins: pharmacological actions beyond anti-malarial

WE Ho, HY Peh, TK Chan, WSF Wong - Pharmacology & therapeutics, 2014 - Elsevier
Artemisinins are a family of sesquiterpene trioxane lactone anti-malarial agents originally
derived from Artemisia annua L. The anti-malarial action of artemisinins involves the …

Plant-microbial interaction: The mechanism and the application of microbial elicitor induced secondary metabolites biosynthesis in medicinal plants

I Chamkhi, T Benali, T Aanniz, N El Menyiy… - Plant Physiology and …, 2021 - Elsevier
Plants and microbes interact with each other via different chemical signaling pathways. At
the risophere level, the microbes can secrete molecules, called elicitors, which act on their …

[HTML][HTML] Drug repurposing and human parasitic protozoan diseases

KT Andrews, G Fisher, TS Skinner-Adams - International Journal for …, 2014 - Elsevier
Parasitic diseases have an enormous health, social and economic impact and are a
particular problem in tropical regions of the world. Diseases caused by protozoa and …

Qinghaosu (artemisinin): the price of success

NJ White - Science, 2008 - science.org
Artemisinin and its derivatives have become essential components of antimalarial treatment.
These plant-derived peroxides are unique among antimalarial drugs in killing the young …

[PDF][PDF] The potential of secondary metabolites from plants as drugs or leads against protozoan neglected diseases-part II

TJ Schmidt, SA Khalid, AJ Romanha, TMA Alves… - 2012 - lavierebelle.org
Infections with protozoan parasites are a major cause of disease and mortality in many
tropical countries of the world. Diseases caused by species of the genera Trypanosoma …

[HTML][HTML] Artemisinins: their growing importance in medicine

S Krishna, L Bustamante, RK Haynes… - Trends in pharmacological …, 2008 - cell.com
Artemisinins are derived from extracts of sweet wormwood (Artemisia annua) and are well
established for the treatment of malaria, including highly drug-resistant strains. Their efficacy …

Nutritional characterisation and antioxidant capacity of different tissues of Artemisia annua L.

EA Brisibe, UE Umoren, F Brisibe, PM Magalhäes… - Food chemistry, 2009 - Elsevier
Evaluation of different tissues of Artemisia annua for their nutritional contents and
antioxidant potential demonstrated that the leaves and inflorescences had the highest …

Review on Experimental Treatment Strategies Against Trypanosoma cruzi

AL Mazzeti, P Capelari-Oliveira, MT Bahia… - Journal of …, 2021 - Taylor & Francis
Chagas disease is a neglected tropical disease caused by the protozoan Trypanosoma
cruzi. Currently, only nitroheterocyclic nifurtimox (NFX) and benznidazole (BNZ) are …

Artemisinin production in Artemisia annua: studies in planta and results of a novel delivery method for treating malaria and other neglected diseases

PJ Weathers, PR Arsenault, PS Covello… - Phytochemistry …, 2011 - Springer
Artemisia annua L. produces the sesquiterpene lactone, artemisinin, a potent antimalarial
drug that is also effective in treating other parasitic diseases, some viral infections and …

Artemisinin triggers induction of cell-cycle arrest and apoptosis in Leishmania donovani promastigotes

R Sen, S Bandyopadhyay, A Dutta… - Journal of medical …, 2007 - microbiologyresearch.org
A major impediment to effective anti-leishmanial chemotherapy is the emergence of drug
resistance, especially to sodium antimony gluconate, the first-line treatment for …