The vast interindividual clinical variability observed in any microbial infection—ranging from
silent infection to lethal disease—is increasingly being explained by human genetic and …

IL-6 family cytokines are defined by the common use of the signal-transducing receptor
chain glycoprotein 130 (gp130). Increasing evidence indicates that these cytokines are …

IL-6 is a pleiotropic cytokine with broad-ranging effects within the integrated immune
response. One of the roles of IL-6 is to support immunocompetence, defined as the ability of …

Since their discovery in patients with autosomal dominant (AD) chronic mucocutaneous
candidiasis (CMC) in 2011, heterozygous STAT1 gain-of-function (GOF) mutations have …

Breast cancer is one of the leading causes of mortality in females. Over the past decades,
intensive efforts have been made to uncover the pathogenesis of breast cancer. Interleukin …

Abstract Interleukin-6 (IL-6) is a pleiotropic cytokine with significant functions in the
regulation of the immune system. As a potent pro-inflammatory cytokine, IL-6 plays a pivotal …

Autosomal recessive, complete TYK2 deficiency was previously described in a patient (P1)
with intracellular bacterial and viral infections and features of hyper-IgE syndrome (HIES) …

Anti-cytokine autoantibodies (ACAAs) are increasingly recognized as modulating disease
severity in infection, inflammation and autoimmunity. By reducing or augmenting cytokine …

Anti-cytokine autoantibodies may cause immunodeficiency and have been recently
recognized as 'autoimmune phenocopies of primary immunodeficiencies' and are found in …

Human autoantibodies (auto‐Abs) neutralizing type I IFNs were first discovered in a woman
with disseminated shingles and were described by Ion Gresser from 1981 to 1984. They …