Role of cholinergic signaling in Alzheimer's disease

ZR Chen, JB Huang, SL Yang, FF Hong - Molecules, 2022 - mdpi.com
Acetylcholine, a neurotransmitter secreted by cholinergic neurons, is involved in signal
transduction related to memory and learning ability. Alzheimer's disease (AD), a progressive …

Astrocytes in human central nervous system diseases: a frontier for new therapies

A Verkhratsky, A Butt, B Li, P Illes, R Zorec… - … and Targeted Therapy, 2023 - nature.com
Astroglia are a broad class of neural parenchymal cells primarily dedicated to homoeostasis
and defence of the central nervous system (CNS). Astroglia contribute to the …

Astrocyte function from information processing to cognition and cognitive impairment

M Santello, N Toni, A Volterra - Nature neuroscience, 2019 - nature.com
Astrocytes serve important roles that affect recruitment and function of neurons at the local
and network levels. Here we review the contributions of astrocyte signaling to synaptic …

Dopamine-evoked synaptic regulation in the nucleus accumbens requires astrocyte activity

M Corkrum, A Covelo, J Lines, L Bellocchio… - Neuron, 2020 - cell.com
Dopamine is involved in physiological processes like learning and memory, motor control
and reward, and pathological conditions such as Parkinson's disease and addiction. In …

Diversity and specificity of astrocyte–neuron communication

CA Durkee, A Araque - Neuroscience, 2019 - Elsevier
Astrocytes are emerging as important players in synaptic function, and, consequently, on
brain function and animal behavior. According to the Tripartite Synapse concept, astrocytes …

G-protein-coupled receptors in astrocyte–neuron communication

P Kofuji, A Araque - Neuroscience, 2021 - Elsevier
Astrocytes, a major type of glial cell, are known to play key supportive roles in brain function,
contributing to ion and neurotransmitter homeostasis, maintaining the blood–brain barrier …

Dysfunctional serotonergic neuron-astrocyte signaling in depressive-like states

C González-Arias, A Sánchez-Ruiz, J Esparza… - Molecular …, 2023 - nature.com
Astrocytes play crucial roles in brain homeostasis and are regulatory elements of neuronal
and synaptic physiology. Astrocytic alterations have been found in Major Depressive …

[HTML][HTML] Human astrocytes in the diseased brain

E Dossi, F Vasile, N Rouach - Brain research bulletin, 2018 - Elsevier
Astrocytes are key active elements of the brain that contribute to information processing.
They not only provide neurons with metabolic and structural support, but also regulate …

Calcium signaling in astrocytes and gliotransmitter release

J Goenaga, A Araque, P Kofuji… - Frontiers in synaptic …, 2023 - frontiersin.org
Glia are as numerous in the brain as neurons and widely known to serve supportive roles
such as structural scaffolding, extracellular ionic and neurotransmitter homeostasis, and …

Astrocyte dysfunction in Alzheimer disease

C Acosta, HD Anderson… - Journal of neuroscience …, 2017 - Wiley Online Library
Astrocytes are glial cells that are distributed throughout the central nervous system in an
arrangement optimal for chemical and physical interaction with neuronal synapses and …