The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor regulating the
expression of genes, for instance encoding the monooxygenases cytochrome P450 (CYP) …

Tapinarof, a novel, first-in-class small-molecule topical therapeutic aryl hydrocarbon
receptor (AhR) modulating agent (TAMA), is in clinical development for the treatment of …

Atopic dermatitis (AD) is the most common chronic inflammatory skin disease in the general
population. Skin barrier dysfunction is the central abnormality leading to AD. The cause of …

Dysregulated glucose metabolism is an important characteristic of psoriasis. Cytoskeletal
protein keratin 17 (K17) is highly expressed in the psoriatic epidermis and contributes to …

Aging is the most important risk factor for the development of major life-threatening diseases
such as cardiovascular disorders, cancer, and neurodegenerative disorders. The aging …

Skin, as the outermost organ of the body, is constantly exposed to both intrinsic and extrinsic
causative factors of aging. Intrinsic aging is related to compromised cellular proliferative …

Polycyclic aromatic hydrocarbons (PAHs), dioxin-like compounds (DLCs) and structurally-
related environmental pollutants may contribute to the pathogenesis of various diseases and …

Aging promotes chronic inflammation, which contributes to fibrosis and decreases organ
function. Fibrosis, the excessive synthesis and deposition of extracellular matrix …

Vascular endothelial cells (VECs) that line the interiors of blood vessels participate in
physiological and inflammatory processes. All skin cell types express the aryl hydrocarbon …

The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor from the family
of basic helix-loop-helix transcription factors. Several studies have indicated an important …