Impaired adipogenesis and dysfunctional adipose tissue in human hypertrophic obesity
A Hammarstedt, S Gogg, S Hedjazifar… - Physiological …, 2018 - journals.physiology.org
The subcutaneous adipose tissue (SAT) is the largest and best storage site for excess lipids.
However, it has a limited ability to expand by recruiting and/or differentiating available …
However, it has a limited ability to expand by recruiting and/or differentiating available …
Reading Mendelian randomisation studies: a guide, glossary, and checklist for clinicians
Mendelian randomisation uses genetic variation as a natural experiment to investigate the
causal relations between potentially modifiable risk factors and health outcomes in …
causal relations between potentially modifiable risk factors and health outcomes in …
Sex differences in genomic drivers of adipose distribution and related cardiometabolic disorders: opportunities for precision medicine
HS Lumish, M O'Reilly, MP Reilly - … , thrombosis, and vascular …, 2020 - Am Heart Assoc
This review focuses on the human genetics, epidemiology, and molecular pathophysiology
of sex differences in central obesity, adipose distribution, and related cardiometabolic …
of sex differences in central obesity, adipose distribution, and related cardiometabolic …
[HTML][HTML] Human demographic history impacts genetic risk prediction across diverse populations
The vast majority of genome-wide association studies (GWASs) are performed in
Europeans, and their transferability to other populations is dependent on many factors (eg …
Europeans, and their transferability to other populations is dependent on many factors (eg …
An expanded genome-wide association study of type 2 diabetes in Europeans
To characterize type 2 diabetes (T2D)-associated variation across the allele frequency
spectrum, we conducted a meta-analysis of genome-wide association data from 26,676 T2D …
spectrum, we conducted a meta-analysis of genome-wide association data from 26,676 T2D …
Genetic association of waist-to-hip ratio with cardiometabolic traits, type 2 diabetes, and coronary heart disease
Importance In observational studies, abdominal adiposity has been associated with type 2
diabetes and coronary heart disease (CHD). Whether these associations represent causal …
diabetes and coronary heart disease (CHD). Whether these associations represent causal …
Causal associations of adiposity and body fat distribution with coronary heart disease, stroke subtypes, and type 2 diabetes mellitus: a Mendelian randomization …
CE Dale, G Fatemifar, TM Palmer, J White… - Circulation, 2017 - Am Heart Assoc
Background: The implications of different adiposity measures on cardiovascular disease
etiology remain unclear. In this article, we quantify and contrast causal associations of …
etiology remain unclear. In this article, we quantify and contrast causal associations of …
Modifiable pathways in Alzheimer's disease: Mendelian randomisation analysis
Objective To determine which potentially modifiable risk factors, including socioeconomic,
lifestyle/dietary, cardiometabolic, and inflammatory factors, are associated with Alzheimer's …
lifestyle/dietary, cardiometabolic, and inflammatory factors, are associated with Alzheimer's …
Local genetic correlation gives insights into the shared genetic architecture of complex traits
Although genetic correlations between complex traits provide valuable insights into
epidemiological and etiological studies, a precise quantification of which genomic regions …
epidemiological and etiological studies, a precise quantification of which genomic regions …
Association of genetic variants related to gluteofemoral vs abdominal fat distribution with type 2 diabetes, coronary disease, and cardiovascular risk factors
Importance Body fat distribution, usually measured using waist-to-hip ratio (WHR), is an
important contributor to cardiometabolic disease independent of body mass index (BMI) …
important contributor to cardiometabolic disease independent of body mass index (BMI) …