The neurotransmitter transporters (NTTs) belonging to the solute carrier 6 (SLC6) gene
family (also referred to as the neurotransmitter-sodium-symporter family or Na+/Cl …

This review considers how recent advances in the physiology of ion channels and other
potential molecular targets, in conjunction with new information on the genetics of idiopathic …

The synthesis, release, reuptake, and metabolism of the excitatory and inhibitory
neurotransmitters glutamate and GABA, respectively, are tightly controlled. Given the role …

The concentration of neurotransmitters in the extracellular space is tightly controlled by
distinct classes of membrane transport proteins. This review focuses on the molecular …

Synaptic regulation of the primary inhibitory neurotransmitter γ-aminobutyric acid (GABA) is
essential for brain function. Cerebral GABA homeostasis is tightly regulated through multiple …

Epileptic seizure activity is associated with an imbalance between excitatory and inhibitory
synaptic activities. The latter is mediated by GABA, and several currently used antiepileptic …

The physiological roles of the betaine/GABA transporter (BGT1; slc6a12) are still being
debated. BGT1 is a member of the solute carrier family 6 (the neurotransmitter, sodium …

Abstract Betaine (N-trimethylglycine), a common osmolyte, has received attention because
of the number of clinical reports associating betaine supplementation with improved …

Inhibition of the GABA transporter subtype GAT1 by the clinically available anti‐epileptic
drug tiagabine has proven to be an effective strategy for the treatment of some patients with …

Abstract γ-Aminobutyric acid (GABA) is a major inhibitory neurotransmitter in the nervous
system. It plays a crucial role in many physiological processes. Upon release from the …