BS Meldrum, MA Rogawski - Neurotherapeutics, 2007 - Elsevier
This review considers how recent advances in the physiology of ion channels and other potential molecular targets, in conjunction with new information on the genetics of idiopathic …
NM Rowley, KK Madsen, A Schousboe… - Neurochemistry …, 2012 - Elsevier
The synthesis, release, reuptake, and metabolism of the excitatory and inhibitory neurotransmitters glutamate and GABA, respectively, are tightly controlled. Given the role …
The concentration of neurotransmitters in the extracellular space is tightly controlled by distinct classes of membrane transport proteins. This review focuses on the molecular …
JV Andersen, A Schousboe… - Essays in …, 2023 - portlandpress.com
Synaptic regulation of the primary inhibitory neurotransmitter γ-aminobutyric acid (GABA) is essential for brain function. Cerebral GABA homeostasis is tightly regulated through multiple …
KK Madsen, HS White, A Schousboe - Pharmacology & therapeutics, 2010 - Elsevier
Epileptic seizure activity is associated with an imbalance between excitatory and inhibitory synaptic activities. The latter is mediated by GABA, and several currently used antiepileptic …
SA Kempson, Y Zhou, NC Danbolt - Frontiers in physiology, 2014 - frontiersin.org
The physiological roles of the betaine/GABA transporter (BGT1; slc6a12) are still being debated. BGT1 is a member of the solute carrier family 6 (the neurotransmitter, sodium …
LS Knight, Q Piibe, I Lambie, C Perkins… - Neurochemical …, 2017 - Springer
Abstract Betaine (N-trimethylglycine), a common osmolyte, has received attention because of the number of clinical reports associating betaine supplementation with improved …
KK Madsen, RP Clausen, OM Larsson… - Journal of …, 2009 - Wiley Online Library
Inhibition of the GABA transporter subtype GAT1 by the clinically available anti‐epileptic drug tiagabine has proven to be an effective strategy for the treatment of some patients with …
K Łątka, J Jończyk, M Bajda - International journal of biological …, 2020 - Elsevier
Abstract γ-Aminobutyric acid (GABA) is a major inhibitory neurotransmitter in the nervous system. It plays a crucial role in many physiological processes. Upon release from the …