HOX genes and their role in the development of human cancers

S Bhatlekar, JZ Fields, BM Boman - Journal of molecular medicine, 2014 - Springer
In this review, we summarize published findings on the involvement of HOX genes in
oncogenesis. HOX genes are developmental genes—they code for proteins that function as …

Intrinsically disordered proteins from A to Z

VN Uversky - The international journal of biochemistry & cell biology, 2011 - Elsevier
The ideas that proteins might possess specific functions without being uniquely folded into
rigid 3D-structures and that these floppy polypeptides might constitute a noticeable part of …

[HTML][HTML] The third helix of the Antennapedia homeodomain translocates through biological membranes.

D Derossi, AH Joliot, G Chassaing… - Journal of Biological …, 1994 - Elsevier
The 60-amino acid long homeodomain of Antennapedia crosses biological membranes by
an energy-independent mechanism, a phenomenon abolished by directed mutagenesis …

The developmental gene Knotted-1 is a member of a maize homeobox gene family

E Vollbrecht, B Veit, N Sinha, S Hake - Nature, 1991 - nature.com
Abstract The Knotted-1 (Kn1) locus is defined by several dominant gain-of-function
mutations that alter leaf development. Foci of cells along the lateral veins do not differentiate …

[HTML][HTML] Protein structure determination in solution by NMR spectroscopy.

K Wüthrich - Journal of Biological Chemistry, 1990 - Elsevier
The introduction of nuclear magnetic resonance (NMR) spectroscopy as a second method
for protein structure determination at atomic resolution, in addition to x-ray diffraction in …

New type of POU domain in germ line-specific protein Oct-4

HR Schöler, S Ruppert, N Suzuki, K Chowdhury… - Nature, 1990 - nature.com
MEMBERS of a family of murine octamer-binding proteins inter-act specifically with the
octamer motif, a transcription regulatory element found in the promoter and enhancer …

Homeodomain-DNA recognition

WJ Gehring, YQ Qian, M Billeter… - Cell, 1994 - Elsevier
Homeodomain-DNA Recognition Review Page 1 Cell, Vol. 79, 211-223, July 29, 1994, Copyright
0 1994 by Cell Press Homeodomain-DNA Recognition Review Waiter J. Gehring; Yan Giu …

Positional cloning and characterization of a paired box-and homeobox-containing gene from the aniridia region

CCT Ton, H Hirvonen, H Miwa, MM Weil, P Monaghan… - Cell, 1991 - cell.com
Based on the map location of the aniridia (AN) locus in human chromosomal band 11p13,
we have cloned a candidate AN cDNA (D11S812E) that is completely or partially deleted in …

A knotted1-like homeobox gene in Arabidopsis is expressed in the vegetative meristem and dramatically alters leaf morphology when overexpressed in transgenic …

C Lincoln, J Long, J Yamaguchi, K Serikawa… - The Plant …, 1994 - academic.oup.com
The homeobox gene knotted1 (kn1) was first isolated by transposon tagging a dominant leaf
mutant in maize. Related maize genes, isolated by virtue of sequence conservation within …

Organic synthesis—where now?

D Seebach - Angewandte Chemie International Edition in …, 1990 - Wiley Online Library
Organic chemistry is not a pure science, despite claims to the contrary. However, neither is it
stagnating nor is it in decline. Instead, it is turning its attention to ever more challenging …