Prevalence, treatment, and neural correlates of apathy in different forms of dementia: a narrative review

I Parrotta, S Cacciatore, F D'Andrea, M D'Anna… - Neurological …, 2024 - Springer
Objectives The aim of this review is to provide an overview on prevalence and clinical tools
for the diagnosis of apathy, as well as on neurophysiological and neuroimaging findings …

Altered delay discounting in neurodegeneration: insight into the underlying mechanisms and perspectives for clinical applications

V Godefroy, I Sezer, A Bouzigues… - Neuroscience & …, 2023 - Elsevier
Steeper delay discounting (ie, the extent to which future rewards are perceived as less
valuable than immediate ones) has been proposed as a transdiagnostic process across …

Deciphering the clinico-radiological heterogeneity of dysexecutive Alzheimer's disease

N Corriveau-Lecavalier, LR Barnard, J Lee… - Cerebral …, 2023 - academic.oup.com
Dysexecutive Alzheimer's disease (dAD) manifests as a progressive dysexecutive syndrome
without prominent behavioral features, and previous studies suggest clinico-radiological …

Multidimensional inhibitory signatures of sentential negation in behavioral variant frontotemporal dementia

MN Díaz-Rivera, A Birba, S Fittipaldi, D Mola… - Cerebral …, 2023 - academic.oup.com
Background Processing of linguistic negation has been associated to inhibitory brain
mechanisms. However, no study has tapped this link via multimodal measures in patients …

[HTML][HTML] An ecological approach to identify distinct neural correlates of disinhibition in frontotemporal dementia

D Tanguy, B Batrancourt, A Estudillo-Romero… - NeuroImage: Clinical, 2022 - Elsevier
Disinhibition is a core symptom of many neurodegenerative diseases, particularly
frontotemporal dementia, and is a major cause of stress for caregivers. While a distinction …

Functional connectivity correlates of reduced goal-directed behaviors in behavioural variant frontotemporal dementia

V Godefroy, B Batrancourt, S Charron… - Brain Structure and …, 2022 - Springer
We explored the resting state functional connectivity correlates of apathy assessed as a
multidimensional construct, using behavioral metrics, in behavioral variant frontotemporal …

Disentangling clinical profiles of apathy in behavioral variant frontotemporal dementia

V Godefroy, B Batrancourt, S Charron… - Journal of …, 2022 - content.iospress.com
Background: Apathy is highly frequent in behavioral variant frontotemporal dementia
(bvFTD). It is presumed to involve different pathophysiological mechanisms and …

Behavioral disinhibition in stroke

WK Tang, E Hui, TWH Leung - Frontiers in Neurology, 2024 - frontiersin.org
Background Post-stroke behavioral disinhibition (PSBD) is common in stroke survivors and
often presents as impulsive, tactless or vulgar behavior. However, it often remains …

Proposal for a Mechanistic Disease Conceptualization in Clinical Neurosciences: The Neural Network Components (NNC) Model

M Nassan - Harvard Review of Psychiatry, 2024 - journals.lww.com
Clinical neurosciences, and psychiatry specifically, have been challenged by the lack of a
comprehensive and practical framework that explains the core mechanistic processes of …

A temporal classification method based on behavior time series data in patients with behavioral variant of frontotemporal dementia and apathy

C Peltier, FX Lejeune, LGT Jorgensen… - Journal of Neuroscience …, 2022 - Elsevier
Background Apathy is a common behavioral syndrome that occurs across neurological and
psychiatric disorders. An influential theoretical framework defined apathy as the quantitative …