Drugs with low water solubility are predisposed to low and variable oral bioavailability and,
therefore, to variability in clinical response. Despite significant efforts to “design in” …

Over 40% of active pharmaceutical ingredients (API) in development pipelines are poorly
water-soluble drugs which limit formulation approaches, clinical application and …

Nanoparticles bring many benefits to pulmonary drug delivery applications, especially for
systemic delivery and drugs with poor solubility. They have recently been explored in …

Solid dispersion has been a topic of interest in recent years for its potential in improving oral
bioavailability, especially for poorly water soluble drugs where dissolution could be the rate …

Introduction: Present article reviews solid dispersion (SD) technologies and other patented
inventions in the area of pharmaceutical SDs, which provide stable amorphous SDs. Areas …

This work reviews the examples of the application of lyophilization and its cryogenic
modifications as the production method of solid dispersions and drug nanocrystals, two …

The preparation of pharmaceutical co-crystals using supercritical CO2 (scCO2) is reviewed.
Co-crystallization is an emerging and powerful technique to improve the physicochemical …

The study was designed to investigate the feasibility of supercritical carbon dioxide (scCO2)
processing for the preparation of simvastatin (SIM) solid dispersions (SDs) in …

The objective of the study was to prepare solid dispersions containing a thermally unstable
drug by hot-melt extrusion (HME). Carbamazepine (CBZ) was selected as model drug and …

The present study investigated effect of manufacturing methods such as hot melt extrusion
(HME) and spray drying (SD) on physicochemical properties, manufacturability, physical …