Neutrophils are frontline cells of the innate immune system. These effector leukocytes are
equipped with intriguing antimicrobial machinery and consequently display high cytotoxic …

The chemokine receptors CXCR1/2 and their ligand CXCL8 are essential for the activation
and trafficking of inflammatory mediators as well as tumor progression and metastasis. The …

The chemokine receptor CXCR2 and its ligands are implicated in the progression of tumours
and various inflammatory diseases. Activation of the CXCLs/CXCR2 axis activates multiple …

The pathology of psoriasis strongly depends on IL-17A. Monoclonal antibodies blocking
either the cytokine or its receptor are among the most efficient treatments for psoriatic …

Skin is the largest organ of the human body. Being the interface between the body and the
outer environment, makes it susceptible to physical injury. To maintain life, nature has …

Neutrophil infiltration into inflamed and infected tissues is a fundamental process of the
innate immune response. While neutrophil interactions with the blood vessel wall have been …

Leukotrienes, a class of arachidonic acid–derived bioactive molecules, are known as
mediators of allergic and inflammatory reactions and considered to be important drug …

Leukotrienes (LTs) are lipid mediators that play pivotal roles in acute and chronic
inflammation and allergic diseases. They exert their biological effects by binding to specific …

Psoriasis is a chronic inflammatory skin disease that severely affects patients physiologically
and psychologically. The pathogenesis involving communication between psoriatic …

Chronic itch remains a highly prevalent disorder with limited treatment options. Most chronic
itch diseases are thought to be driven by both the nervous and immune systems, but the …